LIM Kinase

The LIM kinase family consists of just two members: LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2). With uniquely organised signalling domains, LIM kinases are regulated by several upstream signalling pathways, principally acting downstream of Rho GTPases to influence the architecture of the actin cytoskeleton by regulating the activity of the cofilin family proteins cofilin1, cofilin2 and destrin. Although the LIM kinases are very homologous, particularly when comparing kinase domains, there is emerging evidence that each may be subject to different regulatory pathways and may contribute to both distinct and overlapping cellular and developmental functions.

Cat. No.	Product name	CAS No.	Purity
T15809	LY2812223	1311385-20-2	98%
LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, res...
T7128	TH-257	2244678-29-1	98%
TH 257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
T3960	T56-LIMKi	924473-59-6	98%
T56-LIMKi is a selective inhibitor of LIMK2.
T4598	BMS-5	1338247-35-0	98%
BMS-5 is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.
T12609	R-10015	2097938-51-5	98%
R-10015 is a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket(IC50 of 38 nM for human LIMK1),and a broad-spectrum a...
T24410	LIMK-IN-22j	1116571-01-7	98%
LIMK-IN-22j is an effective and selective inhibitor of LIMK.
T4600	BMS-3	1338247-30-5	98%
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
T15798	LX7101	1192189-69-7	98%
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

T15809

LY2812223

1311385-20-2

98%

LY2812223 is a highly effective and functionally selective mGlu2 receptor agonist. It has a mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, res...

T7128

TH-257

2244678-29-1

98%

TH 257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).

T3960

T56-LIMKi

924473-59-6

98%

T56-LIMKi is a selective inhibitor of LIMK2.

T4598

BMS-5

1338247-35-0

98%

BMS-5 is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively.

T12609

R-10015

2097938-51-5

98%

R-10015 is a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket(IC50 of 38 nM for human LIMK1),and a broad-spectrum a...

T24410

LIMK-IN-22j

1116571-01-7

98%

LIMK-IN-22j is an effective and selective inhibitor of LIMK.

T4600

BMS-3

1338247-30-5

98%

BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.

T15798

LX7101

1192189-69-7

98%

LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).