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MELK

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T79582 Antitumor agent-116 98%
Antitumor agent-116
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for ...
T11732 JTV-519 hemifumarate 1435938-25-2 98%
JTV-519 hemifumarate
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a p...
T35342 MELK-8a Dihydrochloride 98%
MELK-8a Dihydrochloride
MELK-8a Dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T35342.
T11996 MELK-8a hydrochloride 2096992-20-8 99.87%
MELK-8a hydrochloride
MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). 
T11997 MELK-IN-1 2095596-44-2 99.14%
MELK-IN-1
MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
T12237 NMS-P715 1202055-32-0 98.41%
NMS-P715
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T24152 HTH-01-091 2000209-42-5 98.40%
HTH-01-091
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
T1759 OTSSP167 1431697-89-0 98.37%
OTSSP167
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
T21559 OTSSP167 hydrochloride 1431698-10-0 98%
OTSSP167 hydrochloride
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
Antitumor agent-116
T79582
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for ...
JTV-519 hemifumarate
T11732
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a p...
MELK-8a Dihydrochloride
T35342
MELK-8a Dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T35342.
MELK-8a hydrochloride
T11996
MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM). 
MELK-IN-1
T11997
MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
NMS-P715
T12237
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
HTH-01-091
T24152
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM).HTH-01-091 inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK...
OTSSP167
T1759
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
OTSSP167 hydrochloride
T21559
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
TargetMol