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PI3K/Akt/mTOR signaling MELK

MELK

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene. MELK is a serine/threonine kinase belonging to the family of AMPK/Snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos. MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.
Cat No. product name
T1759 OTSSP167 MELK Inhibitor OTS167 is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
T11732 JTV-519 hemifumarate JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a...
T11996 MELK-8a hydrochloride MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor.(IC50:2 nM). 
T11997 MELK-IN-1 MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
T21559 OTSSP167 hydrochloride OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
OTSSP167
T1759CAS 1431697-89-0
MELK Inhibitor OTS167 is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
JTV-519 hemifumarate
T11732CAS 1435938-25-2
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a...
MELK-8a hydrochloride
T11996CAS 2096992-20-8
MELK-8a hydrochloride is a novel maternal embryonic leucine zipper kinase (MELK) inhibitor.(IC50:2 nM). 
MELK-IN-1
T11997CAS 2095596-44-2
MELK-IN-1 is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
OTSSP167 hydrochloride
T21559CAS 1431698-10-0
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).