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PAD

In enzymology, a protein-arginine deiminase is an enzyme that catalyzes a form of post translational modification called arginine de-imination or citrullination. his chemical reaction induces citrullinated proteins formation with altered structure and function, leading to numerous pathological diseases, including inflammation and autoimmune diseases. These pathologies established the PADs as therapeutic targets and multiple PAD inhibitors are known. Humans encode five PADs, designated PADs 1-4 and PAD6. Of the five PAD isozymes (PAD1, 2, 3, 4 and 6), only four (PADs1-4) are catalytically active. PAD activity is tightly regulated by Ca2+ and PADs contain 4 (PAD1), 5 (PAD3, 4) or 6 (PAD2) Ca2+-binding sites. Dysregulated PAD activity, most notably PAD2 and PAD4, is associated with multiple inflammatory diseases (e.g., rheumatoid arthritis) as well as cancer, and PAD inhibitors, such as Cl-amidine and BB-Cl-amidine, show efficacy in multiple preclinical animal models of disease.
Cat No. product name
T2205 Acefylline Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T22277 BMS-P5 BMS-P5 is a novel Peptidylarginine Deiminase 4 (PAD4) inhibitor that blocks delays progression of multiple myeloma and formation of neutrophil extracellular tr...
T24105 GSK121 GSK121 is an inhibitor of selective PAD4.
T22277L BMS-P5 free base BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Del...
T8861 GSK199 GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium).
T10482 BB-Cl-Amidine BB-Cl-Amidine is an inhibitor of peptidyl arginine deminase (PAD).
T10831L Cl-amidine hydrochloride Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in can...
TQ0067 GSK484 hydrochloride GSK484 hydrochloride (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC...
Acefylline
T2205
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
BMS-P5
T22277
BMS-P5 is a novel Peptidylarginine Deiminase 4 (PAD4) inhibitor that blocks delays progression of multiple myeloma and formation of neutrophil extracellular tr...
GSK121
T24105
GSK121 is an inhibitor of selective PAD4.
BMS-P5 free base
T22277L
BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 Blocks Formation of Neutrophil Extracellular Traps and Del...
GSK199
T8861
GSK199 is a selective PAD4 inhibitor(IC50 of 200 nM in the absence of calcium).
BB-Cl-Amidine
T10482
BB-Cl-Amidine is an inhibitor of peptidyl arginine deminase (PAD).
Cl-amidine hydrochloride
T10831L
Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in ca...
GSK484 hydrochloride
TQ0067
GSK484 hydrochloride (GTPL8577) is a specifc and reversible peptidyl arginine deiminase 4 (PAD4) inhibitor. It demonstrates high-affinity binding to PAD4 with IC...