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Sodium-dependent phosphate transporter

Sodium-dependent phosphate transporter refers to a type of membrane protein that facilitates the transport of phosphate ions across cell membranes. This transporter is dependent on the sodium gradient, which is maintained by the sodium-potassium pump, to drive the movement of phosphate against its concentration gradient. This process is essential for maintaining phosphate homeostasis in cells and organisms. It is mainly divided into PIT-1, PIT-2 and PIT-3 subtypes, which have different tissue distribution and functions.

PF-06869206
TQ00112227425-05-8
PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).
  • $33
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Lifastuzumab
T773841615697-16-9
lifastuzumAb is a humanized IgG1-like monoclonal antibody against NaPi2b, often coupled with the anti-mitotic agent monomethyl auristatin E, which inhibits cell division by blocking the polymerization of microtubule proteins.
  • $1,690
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