Periplogenin 3-[O-β-glucopyranosyl-(1→4)-β-sarmentopyranoside] (Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside]) is a carmenolide extracted from Periploca sepium.
1. Periplocin (Periplocoside) has anti-cancer effects on lung cancer cells, induces apoptosis and inhibits growth of cancer cells by the beta-catenin Tcf signaling pathway. 2. Periplocin is used for treatment of rheumatoid arthritis, reinforcement of bones and tendons, palpitations or shortness of breath and lower extremity edema in traditional medicine.
1. Periplogenin (Desoxostrophanthidin) plays protective roles against thyrotoxicosis and associated cardiovascular problems, are mediated through its direct antithyroidal and or LPO inhibiting properties.
Periplocoside M possesses observably antitumor activity against SMMC-7721( IC 50=12.9 ng L),Hela( IC 50=8.63 ng L) and MCF-7( IC 50=18.5 ng L) cancer cell lines.