2,4'-Dihydroxybenzophenone can effectively protect C57BL 6J mice from APAP-induced hepatotoxicity. Its mechanisms might be associated with its Antioxidant activity.
(-)-Hydroxycitric acid (HCA) can inhibit fat synthesis and reduces food intake, the primary mechanism of action of HCA appears to be related to its ability to act as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), primary building blocks of fatty acid and cholesterol synthesis.
3-(3-Hydroxy-3-methylbutanyl)-2,4,6-trihydroxybenzophenone is a natural product for research related to life sciences. The catalog number is TN2862 and the CAS number is 1432062-53-7.
Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
GB 2a shows antioxidant and anti-inflammatory effects, it can prevent the carrageenan-induced paw oedema. GB 2a biflavonoid can promote inhibition on tyrosinase activity and reduced melanin biosynthesis in B16F10 cells, which suggests great potential for
Mangostanol is an acetylcholinesterase (AChE) selective inhibitor.Mangostanol has anti-cancer activity, it shows significant activities against the CEM-SS cell line, with IC50 values of 9.6 microg/ml.
Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations.
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells.
6-Benzoyl-5,7-dihydroxy-2,2-dimethylchromane is a natural product for research related to life sciences. The catalog number is TN3154 and the CAS number is 86606-14-6.
8-Benzoyl-5,7-dihydroxy-2,2-dimethylchromane is a natural product for research related to life sciences. The catalog number is TN3272 and the CAS number is 63565-07-1.
6-Prenylapigenin(4',5,7-Trihydroxy-6-prenylflavone) shows potent inhibitory activity on melanin formation, it may be potential sources for skin whitening agents. It also shows moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarci
Nigrolineaxanthone V is a natural product of Garcinia, Clusiaceae. The catalog number is TN4657 and the CAS number is 864516-31-4. Nigrolineaxanthone V can be used as a reference standard.
Latisxanthone C shows inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells, it may be a valuable antitumor promoter.
2,2',3'-Trihydroxy-4,6-dimethoxybenzophenone is a natural product for research related to life sciences. The catalog number is TN2677 and the CAS number is 219861-73-1.
1,7-Dihydroxy-3-methoxy-2-prenylxanthone is a natural product for research related to life sciences. The catalog number is TN2518 and the CAS number is 77741-58-3.
3-Isomangostin hydrate formate is a natural product for research related to life sciences. The catalog number is TN2955 and the CAS number is 925705-36-8.
3-Prenyl-2,4,6-trihydroxybenzophenone is a natural product for research related to life sciences. The catalog number is TN2983 and the CAS number is 93796-20-4.
Isonormangostin is a natural product of Garcinia, Clusiaceae. The catalog number is TN4316 and the CAS number is 15404-80-5. Isonormangostin can be used as a reference standard.
1,4,5,6-Tetrahydroxy-7-prenylxanthone exhibits anti-cancer activity, demonstrating moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, and shows moderate activity with GI50 values of 2.8 μM against the human leukaemic HL-60 cell line measured in vitro.
1,4,5,6-Tetrahydroxy-7,8-diprenylxanthone exhibits moderate cytotoxicity against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacks antifungal activity against [Candida albicans].
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mitochondrial apoptotic pathway accompanying with ROS production. It can inhibit tumor metastasis
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standard drug amoxicillin. Isojacareubin is a potent inhibitor of protein kinase C (PKC), suppresses
1,5-Dihydroxyxanthone exhibits the epidermal growth factor receptor (EGFR) -tyrosine kinase inhibitory activity, with the IC50 value of 90.34 nM. It may have anticholinesterase activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzym
6-Deoxyisojacareubin shows moderate inhibitory activity against the QGY-7703 cell line, with the IC50 value of 9.65 uM; it also possesses potency in the inhibition of protein kinase C (PKC).
9-Hydroxycalabaxanthone exhibits cytotoxicity against the HT-29 cell line with ED50 values of 9.1 microM. The combination of 9-hydroxycalabaxanthone with α±-mangostin shows the synergistic antimalarial interaction in both clones.