(-)-Corynoxidine is an AChE inhibitor derived from tubers of Stephania succifera. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus strains in different degrees.
Dicentrine, a selective α±(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain.
l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activities with IC(50) ranged from 1.2 uM to 52.3 uM. Stephanine and crebanine have high inhibitory activity against gram-positive animal pathogenic bacteria, with MIC values of 0.078-0.312g/l, but low inhibitory activity against gram-negative animal pathogenic bacteria, they also inhibit hyphal growth of the plant pathogens Cercospora kaki.
(-)-Salutaridine is a natural product isolated from Stephania epigaea Lo.Sinoacutine has protective effects against hydrogen peroxide-induced cell injury.
Dehydrocrebanine has strong activity against promyelocytic leukemia cells (HL-60) with an IC50 of 2.14 ug/mL. It also shows potent antimalarial activity with an IC50 value of 70 ng/ml.
Oblongine chloride may have potential haemodynamic effects, it can cause a dose-dependent reduction of systolic and diastolic blood pressure, and that these effects are not mediated by α²-adrenergic receptor stimulation.
16-Oxoprometaphanine is a natural product of Stephania, Menispermaceae. The catalog number is TN6023 and the CAS number is 58738-31-1. 16-Oxoprometaphanine can be used as a reference standard.
1. Columbin has anti-inflammatory activity. 2. Columbin has chemopreventive ability against human colon cancer. 3. Columbin inhibits PLA2 hydrolysis of ghost RBC in a dose-dependent fashion.
Dihydroepistephamiersine 6-acetate is a natural product for research related to life sciences. The catalog number is TN3850 and the CAS number is 57361-74-7.
1. Crebanine iv 5mg/kg can eonvert BaCl_2-induced arrhythmia into sinus rhythm in rats, and can significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. 2. Crebanine can also decrease t
Epistephamiersine is a natural product of Stephania, Menispermaceae. The catalog number is TN6018 and the CAS number is 52389-15-8. Epistephamiersine can be used as a reference standard.
11-Hydroxyjasmonic acid is a natural product of Stephania, Menispermaceae. The catalog number is TN2585 and the CAS number is 140447-14-9. 11-Hydroxyjasmonic acid can be used as a reference standard.
Tetrandrine (Sinomenine A) is a natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant. Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects.
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue