1438071-12-5

GSK2945 is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.

GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.

GSK2945 hydrochloride is a tertiary amine and a highly specific antagonist of Rev-erbα/REV-ERBα (mouse/human reverse erythropoietic virus α) with an EC50 value of 21.5 μM and 20.8 μM, respectively.GSK2945 hydrochloride increases cholesterol 7α-hydroxylase ( The EC50 values were 21 μM and 20 μM, respectively.