2 nitrobenzaldehyde semicarbazone 13c,15n2

2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.

Zanamivir-13C,15N2is intended for use as an internal standard for the quantification of zanamivir by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50values ranging from 0.6 to 7.9 nMin vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza. 1.Elliott, M.Zanamivir: From drug design to the clinicPhilos. Trans. R. Soc. Lond. B Biol Sci.356(1416)1885-1893(2001)

Uric acid-13C-15N2 is the 13C and 15N labeled compound of Uric acid. Uric acid has a CAS number of 69-93-2. Uric acid is an oxidation product of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

Phthalic acid, bis-4-methyl-2-pentyl ester-d4 is a deuterated compound of Phthalic acid, bis-4-methyl-2-pentyl ester. Phthalic acid, bis-4-methyl-2-pentyl ester has a CAS number of 146-50-9.

Phthalic acid, bis-2-n-butoxyethyl ester-d4 is a deuterated compound of Phthalic acid, bis-2-n-butoxyethyl ester. Phthalic acid, bis-2-n-butoxyethyl ester has a CAS number of 117-83-9.

Bis(2-methoxyethyl) Phthalate-3,4,5,6-d4 is a deuterated compound of Bis(2-methoxyethyl) Phthalate. Bis(2-methoxyethyl) Phthalate has a CAS number of 117-82-8.

(1'S,2'S)-Nicotine-1'-Oxide-d3 is a deuterated compound of (1'S,2'S)-Nicotine-1'-Oxide. (1'S,2'S)-Nicotine-1'-Oxide has a CAS number of 51095-86-4. Nicotine 1'-N-oxide is a natural product from tobacco smoke.

2-NP-AOZ-d4 is a deuterated compound of 2-NP-AOZ. 2-NP-AOZ has a CAS number of 19687-73-1. 2-NP-AOZ is a chemical compound that is a 2-nitrophenyl derivative of AOZ, which is a tissue-bound metabolite of Furazolidone. 2-NP-AOZ is specifically used for the determination of AOZ residues.

2-NP-AMOZ-d5 is a deuterated compound of 2-NP-AMOZ. 2-NP-AMOZ has a CAS number of 183193-59-1. 2-NP-AMOZ is a 2-nitrophenyl derivative of AMOZ, which is a metabolite of the antibiotic Furaltadone. This chemical compound specifically serves as a reliable tool for protein bound AMOZ detection.

2-Phenylethyl Acetate-d3 is a deuterated compound of 2-Phenylethyl Acetate. 2-Phenylethyl Acetate has a CAS number of 103-45-7. 2-Phenylethyl Acetate is a natural product.

2-hydroxy-4-methoxybenzophenone-d5 is a deuterated compound of 2-hydroxy-4-methoxybenzophenone. 2-hydroxy-4-methoxybenzophenone has a CAS number of 131-57-7. Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone.

3 Hydroxy Midostaurin Epimer 2-d5 is a deuterated compound of 3 Hydroxy Midostaurin Epimer 2.3 Hydroxy Midostaurin Epimer 2 has a CAS number of 155848-20-7.

6-methyl-2-heptanone-d5 is a deuterated compound of 6-methyl-2-heptanone. 6-methyl-2-heptanone has a CAS number of 928-68-7.

1-Palmitoyl-d9-2-palmitoyl-sn-glycero-3-PE serves as an internal standard for the quantification of 1,2-dipalmitoyl-sn-glycero-3-PE (1,2-DPPE) using GC- or LC-MS. 1,2-DPPE, a prevalent PE (phospholipid), contains C16:0 fatty acids at the sn-1 and sn-2 positions and is essential in the inner plasma membrane leaflet. This compound forms a condensed lipid monolayer with cholesterol through tight hydrogen bonding between 1,2-DPPE headgroups, enhancing membrane fluidity to support transport and signaling.

dimethyl 2-(methyl-d3)malonate is a deuterated compound of dimethyl 2-(methyl)malonate. dimethyl 2-(methyl)malonate has a CAS number of 516-05-2. Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A. It is an indicator of Vitamin B-12 deficiency in cancer.

4,6-Dimethoxy-2-isothiocyanatopyrimidine-d6 is a deuterated compound of 4,6-Dimethoxy-2-isothiocyanatopyrimidine. 4,6-Dimethoxy-2-isothiocyanatopyrimidine has a CAS number of 110860-38-3.

2-Ethyl-2-phenylmalonamide-d5 is a deuterated compound of 2-Ethyl-2-phenylmalonamide.

2-Methylpropanedioic acid-d3 is a deuterated compound of 2-Methylpropanedioic acid. 2-Methylpropanedioic acid has a CAS number of 516-05-2. Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A. It is an indicator of Vitamin B-12 deficiency in cancer.

Propan-d7-2-amine hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T64769.

2-(Propyl-3,3,3-d3)pentanoic-5,5,5-d3 Acid is a deuterated compound of 2-pentanoic Acid. 2-pentanoic Acid has a CAS number of 99-66-1. Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various molecular mechanisms of action of Valproic Acid have not been completely elucidated. Valproic Acid has been reported to be a potent inhibitor of histone deacetylases (HDACs) in vitro. Valproic Acid is also noted to relieve HDAC-dependent transcriptional repression and causes the hyperacetylation of histones in cultured cells. Additionally, Valproic Acid is reported to activate Wnt-dependent gene expression and to mimic trichostatin A (sc-3511) in the inhibition of histone deacetylase.

Adenine-2-d1 is a deuterated compound of Adenine. Adenine has a CAS number of 73-24-5. Adenine, a purine derivative, is a nucleobase with various roles in biochemistry including cellular respiration, in the form of both the energy-rich ATP and NAD and FAD, and protein synthesis, as a chemical component of DNA and RNA.

1,3-Dichloro-2-propanol-d5 is a deuterated compound of 1,3-Dichloro-2-propanol. 1,3-Dichloro-2-propanol has a CAS number of 96-23-1.

3-Amino-2-Oxazolidinone-d4 is a deuterated compound of 3-Amino-2-Oxazolidinone. 3-Amino-2-Oxazolidinone has a CAS number of 80-65-9. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone. It is always be detected as a indicator of furazolidone residues in vivo.

2-Methoxyestrone-1,4,16,16-d4 is a deuterated compound of 2-Methoxyestrone. 2-Methoxyestrone has a CAS number of 362-08-3. 2-Methoxyestrone is a methoxylated catechol estrogen and the principal metabolite of 2-hydroxyestrone, a nonuterotropic metabolite of estradiol.

1-Palmitoyl-d9-2-palmitoyl-sn-glycerol serves as an internal standard for quantifying 1,2-dipalmitoyl-sn-glycerol using GC or LC-MS techniques. This diacylglycerol, featuring palmitic acid at both the sn-1 and sn-2 positions, stimulates protein kinase C (PKC) activity by 15% at a 25 μM concentration. Additionally, 1,2-dipalmitoyl-sn-glycerol encourages rapid growth in Frankia, a genus of Gram-positive bacteria.

HT-2 toxin-13C22is intended for use as an internal standard for the quantification of HT-2 toxin by GC- or LC-MS. HT-2 toxin is a type A trichothecene mycotoxin and an active, deacetylated metabolite of the trichothecene mycotoxin T-2 toxin .1,2Like T-2 toxin, HT-2 toxin inhibits protein synthesis and cell proliferation in plants.2HT-2 toxin also reduces viability of HepG2, A549, HEp-2, Caco-2, A-204, U937, Jurkat, and RPMI-8226 cancer cells with IC50values ranging from 3.1 to 23 ng/ml and human umbilical vein endothelial cells with an IC50value of 56.4 ng/ml.1It induces oxidative stress, DNA damage, and autophagy in, as well as halts the development of, cultured mouse embryos when used at a concentration of 10 nM.3HT-2 toxin has been found in cereal grains and food products.4,5 1.Nielsen, C., Casteel, M., Didier, A., et al.Trichothecene-induced cytotoxicity on human cell linesMycotoxin Res.25(2)77-84(2009) 2.Nathanail, A.V., Varga, E., Meng-Reiterer, J., et al.Metabolism of the fusarium mycotoxins T-2 toxin and HT-2 toxin in wheatJ. Agric. Food Chem.63(35)7862-7872(2015) 3.Zhang, L., Li, L., Xu, J., et al.HT-2 toxin exposure induces mitochondria dysfunction and DNA damage during mouse early embryo developmentReprod. Toxicol.85104-109(2019) 4.Langseth, W., and Rundberget, T.The occurrence of HT-2 toxin and other trichothecenes in Norwegian cerealsMycopathologia147(3)157-165(1999) 5.Al-Taher, F., Cappozzo, J., Zweigenbaum, J., et al.Detection and quantitation of mycotoxins in infant cereals in the U.S. market by LC-MS/MS using a stable isotope dilution assayFood Control72(Part A)27-35(2017)

Ethephon-d4 (2-Chloroethyl-1,1,2,2-d4) is a deuterated compound of Ethephon. Ethephon has a CAS number of 16672-87-0.

Semicarbazide-13C-15N2 Hydrochloride is the 13C and 15N labeled compound of Semicarbazide Hydrochloride. Semicarbazide Hydrochloride has a CAS number of 563-41-7. Semicarbazide is Snow white crystals and used as a reagent for ketones and aldehydes with which it affords crystalline compounds having characteristic melting points.

2-Chlorophenol-d4 (3,4,5,6-d4) is a deuterated compound of 2-Chlorophenol. 2-Chlorophenol has a CAS number of 95-57-8.

Cefdinir-13C-15N2 is the 13C and 15N labeled compound of Cefdinir. Cefdinir has a CAS number of 91832-40-5. Cefdinir is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat and skin.

2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol-d4 is a deuterated compound of 2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol. 2-(2H-benzotriazol-2-yl)-4,6-di-tert-butylphenol has a CAS number of 3846-71-7.

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PA (1-palmitoyl-d9LPA) serves as an internal standard for the quantification of 1-palmitoyl LPA using GC- or LC-MS. This compound, an analog of LPA with palmitic acid at the sn-1 position, activates reporter gene expression in PC12 cells fitted with human lysophosphatidic acid receptor 4 (LPA4) at 0.01 to 10 µM concentrations. Additionally, 1-palmitoyl LPA prompts aggregation in isolated human platelets within the 12-300 µM range, a process reversible by prostaglandin E1 (PGE1), theophylline, or EDTA. It also interacts with calcium and magnesium to boost the efficacy of ampicillin, piperacillin, and ceftazidime against P. aeruginosa strains from cystic fibrosis patients.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis.

1,3-Distearoyl-2-chloropropanediol-d5 is a deuterated compound of 1,3-Distearoyl-2-chloropropanediol.

2-Furoic Acid-d3 is a deuterated compound of 2-Furoic Acid.

DL-2-Aminooctanoic acid-d14 is a deuterated compound of DL-2-Aminooctanoic acid. DL-2-Aminooctanoic acid has a CAS number of 644-90-6. DL-2-Aminooctanoic acid, also known as a-aminocaprylate or alpha-aminocaprylic acid, belongs to the class of organic compounds known as alpha-amino acids.

2-Nitrotoluene-d7 is a deuterated compound of 2-Nitrotoluene. 2-Nitrotoluene has a CAS number of 88-72-2.

2-Naphthol-d8 is a deuterated compound of 2-Naphthol. 2-Naphthol has a CAS number of 135-19-3. 2-Naphthol is an isomer of 1-naphthol, differing by the location of the hydroxyl group on the naphthalene ring.

2-Butanone 2，4-Dinitrophenylhydrazone-3，5，6-d3 is a deuterated compound of 2-Butanone 2，4-Dinitrophenylhydrazone. 2-Butanone 2，4-Dinitrophenylhydrazone has a CAS number of 958-60-1.

(-)-2-Methyl Isoborneol-d3 is a deuterated compound of (-)-2-Methyl Isoborneol. (-)-2-Methyl Isoborneol has a CAS number of 68330-43-8.

1, 14-tetradecanedioic-2, 2, 13, 13-d4 acid is a deuterated compound of 1, 14-tetradecanedioic acid. 1, 14-tetradecanedioic acid has a CAS number of 821-38-5. Tetradecanedioic acid is a C14 dicarboxylic acid.

DL-2-Hydroxydecanoic acid-d18 is a deuterated compound of DL-2-Hydroxydecanoic acid. DL-2-Hydroxydecanoic acid has a CAS number of 37639-46-6.

2-(1-(methyl-d3)-1H-imidazol-4-yl)ethan-1-amine 2HCl is a deuterated compound of 2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl. 2-(1-(methyl)-1H-imidazol-4-yl)ethan-1-amine 2HCl has a CAS number of 6481-48-7. 1-Methylhistamine dihydrochloride is a major metabolite of histamine by histamine N-methyltransferase in the pathway of histidine metabolism. It has been used as a biomarker of histaminergic system activity in the brains of Alzheimer's disease patients as well as those with hypersomnia and other neurological conditions.

2-chloro-6-methylbenzoic acid-d3 is a deuterated compound of 2-chloro-6-methylbenzoic acid. 2-chloro-6-methylbenzoic acid has a CAS number of 21327-86-6.

1-Palmitoyl-d9-2-hydroxy-sn-glycero-3-PE serves as an internal standard for quantifying 1-palmitoyl-2-hydroxy-sn-glycero-3-PE, a lysophospholipid naturally found to inhibit L. donovani promastigotes growth (GI50= 8 µM). Its levels are reduced in mice after alcohol-induced liver damage, in hepatocellular carcinoma mouse xenografts, and in humans following a rigorous three-day exercise regimen of 2.5 hours running daily and 14 hours post-regimen. This compound is also applied in measuring saturated lysophosphoethanolamines, highlighting its broad utility in biochemical research and disease model studies.

2-Furamide-3,4,5-d3 is a deuterated compound of 2-Furamide-3,4,5.