a 601

A 601 is a lipid A analog derived from N-acylated serine-linked nonphosphorylated acylglucosamine.

RS-601 is a potent dual leukotriene D4/thromboxane A2 inhibitor that inhibits antigen-induced airway hyperresponsiveness (AHR) and shows asthmatic effects in a guinea pig model of asthma.

TRP-601 is a caspase inhibitor. This compound modulates apoptosis pathways by inhibiting caspase enzymes, potentially offering therapeutic benefits in diseases where apoptosis is dysregulated. (Old way)

DO-601 is a stimulant that stimulates the central nervous system.

SPK-601 is an inhibitor of phosphatidylcholine-specific phospholipase C.

Ono EI-601 is the main metabolite of ONO-5046, the human neutrophil elastase inhibitor .

JTH-601 free base is an antagonist of alpha 1 adrenergic receptor.

INSCoV-601I(1) is a potent Mpro(3CLpro) inhibitor linked to viral transcription and replication through proteases (PLpro and 3CLpro). This compound has demonstrated research potential against SARS-CoV-2 infection.

(2S,5S)-Censavudine ((2S,5S)-OBP-601), the (2S,5S)-enantiomer of Censavudine, is a potent nucleoside reverse transcriptase inhibitor and HIV inhibitor.

EGFR HER2-IN-11 (compound 20), an orally active dual inhibitor targeting human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR), demonstrates IC50 values of 7.7 nM and 22 nM, respectively. This compound shows strong antitumor efficacy, specifically inhibiting the proliferation of BT-474 cancer cells with a GI50 of 601 nM [1].

GSK1795091 (CRX-601) is a synthetic TLR4 agonist and immunologic stimulator with demonstrated antitumor activity. It serves as a vaccine adjuvant, enhancing both mucosal and systemic immunity to influenza virus vaccines.

Mipasetamab uzoptirine (ADCT-601) is an antibody-drug conjugate (ADC) targeting AXL, combining a humanized anti-AXL antibody with a cleavable linker and the potent pyrrolobenzodiazepine (PBD) dimer cytotoxin SG3199, used in cancer research [1].

Razupenem ( SMP-601, PTZ601) is a broad-spectrum injectable antibiotic derived from the carbapenem subgroup of β-lactam antibiotics. It has been developed as an alternative drug against bacteria that have developed antibiotic resistance to commonly used a

Mipasetamab, an IgG1κ antibody, targets AXL, a tyrosine kinase receptor and TAM Receptor. It plays a crucial role in synthesizing ADCT-601 (Mipasetamab uzoptirine), an AXL-targeted antibody-drug conjugate (ADC), known for its anti-tumor activity [1].

Ethyl-d5-malonic Acid is a deuterated compound of Ethyl-malonic Acid. Ethyl-malonic Acid has a CAS number of 601-75-2. Ethylmalonic acid can be found in blood, cerebrospinal fluid (CSF), and urine, as well as in human fibroblasts, prostate, and skeletal muscle tissues. Moreover, ethylmalonic acid is found to be associated with anorexia nervosa and malonyl-CoA decarboxylase deficiency. Ethylmalonic acid is a non-carcinogenic potentially toxic compound. Chronically high levels of ethylmalonic acid are associated with at least two inborn errors of metabolism, including short chain acyl CoA dehydrogenase deficiency (SCAD deficiency) and ethylmalonic encephalopathy.

T-705RMP, the phosphorylated metabolite derived from T-705, demonstrates a limited inhibitory impact on the host cells' IMP dehydrogenase (IMPDH) activities, with an IC 50 value of 601 μM.

Censavudine (OBP-601) is a nucleoside analog, a nucleoside reverse transcriptase inhibitor, used for the prevention and treatment of human immunodeficiency virus 1 (HIV-1).Censavudine inhibits HIV-2 and HIV-1. Censavudine inhibits HIV-2 and HIV-1 with EC50 ranges of 30-81 nM and 450-890 nM, respectively.