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Acetyl-L-carnitine(RO 447190) is an amino acid that crosses the blood-brain barrier and is often used as a dietary supplement for neuroinflammation.Acetyl-L-carnitine is neuroprotective and can be used in the study of neurological disorders like Alzheimer's disease.

Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) is a nutritional supplement composed of the hydrochloride salt form of the acetylated form of the endogenously produced L-carnitine, with potential neuroprotective, cognitive-enhancing, anti-depressive and immunomodulating activities. It may also relieve peripheral neuropathy induced by chemotherapy, diabetes or other diseases. In addition, acetyl-L-carnitine may modulate the immune response by increasing T-lymphocytes maturation and may downregulate pro-inflammatory cytokines in response to viruses, such as SARS-CoV-2. It may also disrupt the ACE2 signaling pathway and inhibit the production of reactive oxygen species (ROS).

Falcarinol (Panaxynol) is an Hsp90 inhibitor and CB1 receptor antagonist that inhibits the action of amphetamine on TNF-α-stimulated keratinocytes.

(3S,8R,9R)-Isofalcarintriol, a natural polyacetylene compound present in carrot roots, acts as a potent longevity promoter. It improves glucose metabolism and exhibits antitumor activity by influencing cellular respiration and interacting with the α-subunit of mitochondrial ATP synthase, which promotes mitochondrial biosynthesis. Furthermore, (3S,8R,9R)-Isofalcarintriol is utilized in research related to neurodegenerative diseases, metabolic disorders, and aging.'

1. (+)-(3R,8S)-Falcarindiol is a potential new anticancer agent that exerts its activity through inducing ER stress and apoptosis. 2. Falcarindiol induces immunosuppressive effects in vitro and in vivo and might be a novel therapy for autoimmune or allergic diseases. 3. Falcarindiol has protective effect against CCl(4) toxicity , in part, be explained by anti-lipid peroxidation activity associated with the induction of the GSTs including GSTA4.

Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ, enhancing ABCA1 expression [a cholesterol transporter], and induces apoptosis and autophagy, exhibiting anti-inflammatory, antifungal, anticancer, and antidiabetic properties.