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am 555s

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  • Inhibitors & Agonists
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Amsilarotene
TAC-101, TAC101, TAC 101
T21314125973-56-0
Amsilarotene (TAC101) inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase and cyclin A expression.
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