Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.

LL-37, Human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

EAK16-II, an amphipathic peptide, concentration-dependently inhibits the self-sorting of EAKIIH6 [1].

EB1 peptide (Penetrating analog), an amphipathic cell-penetrating peptide (CPP) derivative of Penetratin, holds promise for intracellular drug delivery research [1].

LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.

KLA peptide is a cationic amphipathic mitochondrial membrane-disrupting peptide that can induce programmed cell death by targeting mitochondrial membranes, yet it lacks the ability to transverse the plasma membrane.

LAH4 TFA, an alpha-helix of the designed amphipathic peptide antibiotic, demonstrates potent antimicrobial, nucleic acid transfection, and cell penetration capabilities, alongside high plasmid DNA delivery capacities. It also exhibits a strong affinity for anionic lipids present in the outer membrane of bacterial membranes [1] [2] [3].

st-Ht31, a cell-permeable stearated peptide derived from the amphipathic helix domain of A-kinase anchoring proteins (AKAPs), effectively binds protein kinase A (PKA), impacting PKA's cellular interactions without altering its activity. Specifically, at a 50 µM concentration, it reduces PKA's membrane anchoring in BHK-21 fibroblast reporter assays. Moreover, st-Ht31 at concentrations of 1 and 3 µM decreases both capacitance and hyperactivation in mouse sperm, thereby inhibiting in vitro fertilization. Additionally, at 50 µM, this compound facilitates cholesterol export in BHK-21 cells and RAW 264.7 macrophages expressing ATP-binding cassette transporter 1 (ABCA1), showcasing its multifaceted cellular impacts.

The a-helix of the amphipathic peptide antibiotic LAH4 (KKALLALALHHLAHLALHLALALKKA-NH2) strongly interacts with phospholipid membranes, demonstrating in vitro transfection efficiencies comparable to those of commercially available reagents.

Magainin 1 is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis.

LL-37, human TFA, is a cathelicidin-derived, 37-residue, amphipathic antimicrobial peptide that displays a broad spectrum of antimicrobial activity. It may protect the cornea from infection and modulate wound healing [1] [2] [3].

LL-37, human acetate, is a 37-residue amphipathic peptide derived from cathelicidin, known for its broad-spectrum antimicrobial properties. This compound not only plays a crucial role in safeguarding the cornea against infection but also modulates wound healing [1] [2] [3].