antipsychotic agent

Antipsychotic agent-2 (Compound 11) is a potent antipsychotic with high affinities for 5-HT 1A, 5-HT 2A, 5-HT 2C, D 2, and H 1 receptors, exhibiting K i values of 56.6, 66.7, 552, 596, and 1140 nM, respectively. It also possesses blood-brain barrier (BBB) permeability [1].

Ziprasidone hydrochloride monohydrate (CP 88059) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of the antipsychotic activity.

Aripiprazole (OPC-14597) is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A.

Ziprasidone (Geodon) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.

Iloperidone (HP 873) is an atypical antipsychotic agent that is used for treatment of schizophrenia.

Risperidone (R 64 766) is a selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that act as an atypical antipsychotic agent.

Pimozide (R6238) is a diphenylbutylpiperidine derivative and a dopamine antagonist with the antipsychotic property. Pimozide selectively inhibits type 2 dopaminergic receptors in the central nervous system (CNS), thereby decreasing dopamine neurotransmission and reducing the occurrence of the motor and vocal tics and delusions of parasitosis. In addition, this agent antagonizes alpha-adrenergic and 5-HT2 receptors.

Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.

Lurasidone hydrochloride (Lurasidone HCl) is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antagonist, an antagonist of the adrenergic α2A and α2C receptors, as well as a partial serotonin 5-HT1A receptor agonist. It is used in the treatment of schizophrenia and bipolar disorder.

SEP-363856 is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.

SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concent

Cariprazine D6 (RGH-188 D6) is a deuterium-labeled Cariprazine. Cariprazine is an antipsychotic agent (D3 receptors, Ki: 0.085 nM; D2 receptors, Ki: 0.49 nM).

Lenperone HCl is a dopamine antagonist and an antipsychotic agent.

Ziprasidone, an antipsychotic agent, functions as a dual antagonist of 5-HT (serotonin) and dopamine receptors. Keto Ziprasidone represents an impurity found within Ziprasidone.

Clozapine HCl is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.

Lurasidone-d8 HCl is a deuterated compound of Lurasidone HCl. Lurasidone HCl has a CAS number of 367514-88-3. Lurasidone hydrochloride is a thiazole derivative and atypical antipsychotic agent that functions as a dopamine D2 receptor antagonist; serotonin 5-HT2 receptor antagonist, serotonin 5-HT7 receptor antagonist, an antagonist of the adrenergic α2A and α2C receptors, as well as a partial serotonin 5-HT1A receptor agonist. It is used in the treatment of schizophrenia and bipolar disorder.

Aripiprazole-d8 is a deuterated compound of Aripiprazole. Aripiprazole has a CAS number of 129722-12-9. Aripiprazole is an antipsychotic agent that is structurally related to piperazines and quinolones. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A.

Trebenzomine is apsychotropic agent with potential as an antidepressant and an antipsychotic.

Asenapine Maleate (Org 5222 maleate) is a second generation (atypical) antipsychotic agent that is taken sublingually and used in the treatment of schizophrenia and manic or mixed episodes associated with bipolar 1 disorder. Asenapine is associated with a low rate of transient and mild serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.

Acetophenazine dimaleate is an antipsychotic agent, effective in anxious depression. Acetophenazine dimaleate primarily targets the dopamine D2 receptor.

Sch 40853 is an active metabolite of a benzonaphthazepine antipsychotic agent.

SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to treatment of schizophrenia.

Cyamemazine, contains the phenothiazine chromophore, is a neuroleptic agent used as an anxiolytic. Cyamemazine is a potent 5-HT3 (Ki: 12 nM), 5-HT2A (Ki: 1.5 nM) and 5-HT2C (Ki: 75 nM) receptors antagonist with antipsychotic activity.

Clothiapine (HF 2159) is an atypical antipsychotic agent with potent anti 5-hydroxytryptaminergic and serotonergic activity, which has been used in the study of schizophrenia.

Hydroxy ziprasidone is an impurity of Ziprasidone. Ziprasidone, an antipsychotic agent, is a 5-HT and dopamine receptor antagonist.

Bromperidol decanoate is an antipsychotic agent that is utilized for long-term maintenance treatment for schizophrenia.

Fluphenazine Decanoate Dihydrochloride is an antipsychotic agent, it could block postsynaptic dopamine D2 receptors in the limbic, cortical system and basal ganglia.

Carphenazine is used for the treatment of chronic schizophrenia, which is an antipsychotic agent.

Clozapine-d3 is a deuterated compound of Clozapine. Clozapine has a CAS number of 5786-21-0. Clozapine is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity.

U 101958 is a putative antipsychotic agent It is also a highly selective dopamine D4 receptor antagonist.

BGC20-761 is a selecvtive 5-HT6 and dopamine receptor antagonist (human receptor K i values: 5-HT6 (20 nM), 5-HT2A (69 nM), D2 (140 nM). BGC20-761 is a tryptamine analog with a high affinity for 5-HT(6) receptors, that can enhance long-term memory. BGC20-761 has potential utility as an antipsychotic agent [1].

Haloperidol decanoate (KD 16) is a typical antipsychotic agent utilized as maintenance treatment for schizophrenia and mood disorders formulated as an ester for intramuscular injection.

Zotepine, an antipsychotic agent, is a potent antagonist of 5-HT2A, 5-HT2C, Histamine H1, α1-adrenergic, and Dopamine D2 receptors, with Kds of 2.6 nM, 3.2 nM, 3.3 nM, 7.3 nM, and 8 nM, respectively. Zotepine is a second-generation antipsychotic with a primary use as a treatment for schizophrenia, although clinical trials have been conducted into its efficacy as an antimanic agent in patients with acute bipolar mania.

Thiothixene hydrochloride is an antipsychotic agent that can be used in the study of schizophrenia and bipolar mania.

Remoxipride is an antipsychotic agent. Remoxipride is specific for dopamine D2 receptors.

Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist which is a potent antipsychotic agent.

Perospirone hydrochloride-d8 is a deuterated compound of Perospirone hydrochloride. Perospirone hydrochloride has a CAS number of 129273-38-7. Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia.  It also displays affinity towards 5HT1A receptors as a partial agonist.

Perospirone-d8 HCl is a deuterated compound of Perospirone HCl. Perospirone HCl has a CAS number of 129273-38-7. Perospirone hydrochloride is an atypical antipsychotic agent for the treatment of schizophrenia.  It also displays affinity towards 5HT1A receptors as a partial agonist.

Amperozide (FG 5606) is a diphenylbutylpiperazine atypical antipsychotic which antagonizes 5-HT2A receptors. It inhibits dopamine release and alters the firing of dopaminergic neurons. Investigations regarding the use of the agent revolved primarily around its capability for treating schizophrenia in humans.

Fluspiperone is an antipsychotic agent.

Flutroline is a gamma-carboline antipsychotic agent.

(±)-Levomepromazine is the Levomepromazine racemate. Levomepromazine is an orally active and typical antipsychotic agent [1].

Bromperidol hydrochloride (R-11333 hydrochloride) is an antipsychotic agent with good affinity for the central dopamine receptors D2. Spectinomycin synergistically kills mycobacteria.

Alpertine is an antipsychotic agent.

Perospirone hydrochloride (Perospirone HCl) is an atypical antipsychotic agent for the treatment of schizophrenia. It also displays affinity towards 5HT1A receptors as a partial agonist.