at 61

AT-61 is a nonnucleoside analogue inhibitor of hepatitis B virus (HBV) replication.

BAY 61-3606 (Syk inhibitor IV) is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki= 7.5 nM), exhibiting no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.

Compound 5b (Anti-inflammatory agent 61) is a potent anti-inflammatory agent that diminishes TNF-α expression in LPS-induced inflammation within RAW 264.7 cells and mitigates APAP-induced inflammation in HepG2 cells [1].

α-Synuclein (61-95) (human) constitutes the hydrophobic core of α-synuclein and is implicated in inducing neuronal cell death. This segment is utilized in the study of neurodegenerative conditions such as Alzheimer's disease (AD) and Parkinson's disease (PD) [1] [2].

Influenza Matrix Protein (61-72) is a peptide derived from the matrix protein of influenza viruses and encompasses amino acids 61-72. This specific epitope, Influenza Matrix Protein (61-72), has the ability to elicit a CD4+ T-cell response.

α-Synuclein (61-75) is a peptide fragment derived from the larger protein α-Synuclein. α-Synuclein is predominantly found in presynaptic nerve terminals and is considered to be a biomarker candidate for Parkinson's disease (PD).

Lactoferricin H, Lactotransferrin (37-61), human, is a bioactive peptide with antimicrobial properties, derived from the amino acid residues 37-61 of human lactotransferrin.

Antifungal Agent 61 (Compound 38) is an antifungal agent that inhibits V. mali, with an EC50 value of 0.50 mg/L. This compound impedes V. mali's growth by inducing cell deformation and contraction, diminishing intracellular mitochondrial count, thickening the cell wall, and enhancing cell membrane permeability [1].

α-Synuclein (61-75) TFA is a fragment (residues 61-75) of the abundant neuronal protein α-Synuclein, which is predominantly located in presynaptic nerve terminals. α-Synuclein serves as a potential biomarker for Parkinson's disease (PD) [1] [2].

HLCL-61 hydrochloride (HLCL-61 HCL) is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.

Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.

Anticancer agent 61 is an orally active anticancer agent. anticancer agent 61 was able to inhibit the proliferation of HepG2, Bel-7402 and MCF-7 cancer cells with IC50 values of 1.12, 1.97 and 1.08 μM respectively. anticancer agent 61 inhibited tumour Anticancer agent 61 was able to inhibit tumour growth.

β-Lipotropin (61-69) is a potent opioid agonist [1] [2] .

Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity, as evidenced by its IC50 values ranging from 0.92 to 3.23 μM against six human cancer cell lines: SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549, and MG-63. It specifically induces apoptosis in SK-OV-3 cells via mitochondrial pathways [1].

HDAC-IN-61 (compound 12k) is a potent, orally active inhibitor of histone deacetylase (HDAC) with anticancer activity, exhibiting an IC50 of 30 nM against Bel-7402 cells, and is utilized for cancer research [1].

KRAS G12C inhibitor 61 (Example 3) demonstrates potent activity by inhibiting phospho-ERK 1/2 in MIA PaCa-2 cells, reflected in an IC50 value of 9 nM. This inhibitor is applicable in the research of pancreatic, colorectal, and lung cancers [1].

EGFR-IN-61 (compound 22a), a potent EGFR kinase inhibitor, exhibits IC50 values of 42 nM for L858R/T790M, 137 nM for L858R/T790M/C797S, and 743 nM for WT. Additionally, it demonstrates antiproliferative activity against the A549 and H1975 cell lines, with IC50 values of 2.14 μM and 1.82 μM, respectively [1].

ARD-61 is a potent and specific PROTAC androgen receptor (AR) degrader, exhibiting high effectiveness. It effectively induces the degradation of AR and progesterone receptors (PR) in AR+ cancer cell lines, leading to apoptosis. Additionally, ARD-61 demonstrates significant tumor growth inhibition in the MDA-MB-453 xenograft model in mice.

LCMV GP (61-80) is a peptide fragment derived from LCMV glycoprotein (GP) and corresponds to amino acids 61-80. This specific epitope, LCMV GP (61-80), has the ability to elicit CD4+ T-cell response.

BAY 61-3606 dihydrochloride (BAY 61-3606) is a potent and selective inhibitor of Syk kinase (Ki = 7.5 nM).

BAY 61-3606 HCl is a cell-permeable, reversible inhibitor of spleen tyrosine kinase. BAY 61-3606 HCl can inhibit degranulation and block cytokine release from mast cells. Oral administration of BAY 61-3606 to rats was shown to suppress antigen-induced passive cutaneous anaphylactic reaction, bronchoconstriction, and bronchial edema. It can also sensitize MCF-7 breast cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis by inhibiting Cdk9. This compound has been used in a pre-clinical model to explore the feasibility of targeting Syk in the treatment of retinoblastoma.

SARS-CoV-2-IN-61 (compound 8i) is a potent inhibitor of the SARS-CoV-2 PLpro, exhibiting an IC50 of 16 µM and demonstrating antiviral activities [1].

Mpro 61 is a potent non-covalent inhibitor of SARS-CoV-2 main protease.

Antibacterial agent 61 (example 27) is a antibacterial agent.

NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.

LB-60-OF61 is a NAMPT inhibitor, a NAMPT inhibitor that displays antiproliferative activity against MYC oncogene-dependent cancer cell lines.

Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1].

Compound 1, identified as a GPR61 inverse agonist, exhibits an IC50 of 11 nM, rendering it suitable for metabolism and body weight disorder research, including obesity and cachexia [1].

Semax acetate is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.

Sec61-IN-5 (Compound 16c), a Sec61 inhibitor, exhibits cytotoxicity in A549 cells with an IC50 of 0.27 nM and impedes Sec61-dependent secretory function with an IC50 of 0.08 nM [1].

Ro 61-1448 is a metabolite of tolcapone, a catechol-O-methyltransferase inhibitor.

Sec61-IN-2 (A347) is a protein secretion inhibitor.

BGC-20-1531 hydrochloride(1186532-61-5 free base) (GTPL3380 hydrochloride) is a EP4 antagonist for the treatment of acute migraine.

BFE-61 is a partial agonist of the beta-adrenoceptors.

RO-61-0593 is a bioactive chemical.

RI 61 (sumatriptan succinate) is utilized in the therapy of migraine, cluster headaches, new daily persistent headache, and cyclic vomiting syndrome.

HT-61, a pyrroloquinolone antibiotic, is used potentially for the treatment of staphylococcal infections.

RO-61-0591 is a bioactive chemical.

STING agonist D61 is a compound that activates the stimulator of interferon genes (STING), leading to the induction of IFN3-inducible secreted alkaline phosphatase (SEAP) and IFN-β-inducible reporter genes in cellular assays, with half-maximal effective concentrations (EC50s) of 52.9 and 116 nM, respectively. At concentrations of 4, 6, and 8 µM, D61 enhances the production of IFN-β and chemokine (C-X-C motif) ligand 10 (CXCL10) mRNA, as well as the phosphorylation of TANK-binding kinase 1 (TBK1), IRF3, and STING in THP-1 monocytes. Additionally, when administered at a dose of 0.25 mg/kg every other day, D61 effectively reduces tumor volume in a CT26 murine colon cancer model without impacting the body weight of the subjects.

JAK1-IN-B61 is a JAK1 inhibitor.

Allergen Gal d 4 (46-61), chicken is a hen egg white lysozyme peptide.

Sec61-IN-2 (A3) is a protein secretion inhibitor.

RO-61-3662 is a bioactive chemical.

LB-60-OF61 hydrochloride is a highly effective inhibitor of NAMPT, a key enzyme involved in the transfer of nicotinamide phosphoribosyl groups. This compound, known for its cytotoxic properties, specifically targets cell lines that overexpress MYC, thereby demonstrating selectivity in its action.

Sec61-IN-1 is a potent sec61 inhibitor.

Osteogenic Growth Peptide, OGP acetate is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marro

BP 897 (2-Naphthalenecarboxamide, N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-) is a potent and selective dopamine D3 receptor agonist, and a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors, and shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 μM, respectively).

BP 897 is a potent and selective agonist of dopamine D3 receptor and it is a weak dopamine D2 receptor antagonist, with Kis of 0.92 nM and 61 nM for D3 and D2 receptors. Which shows low affinities at D1 and D4 receptors (Kis, 3 and 0.3 μM, respectively).

Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity. cis-Resveratrol is the double bond isomer of trans-resveratrol, the more often studied and naturally abundant of the two resveratrol isomers. cis-Resveratrol exhibits antioxidant activity in the µM range similar to that observed with trans-resveratrol. It blocks production of reactive oxygen species (ROS) by inhibition of NAD(P)H oxidase and also inhibits production of nitric oxide. At a concentration of 100 µM, cis-resveratrol significantly inhibits the expression of genes related to the Rel/NF-κB/IκB family, adhesion molecules, and acute-phase proteins in LPS and INF-γ-stimulated murine peritoneal macrophages. cis-Resveratrol inhibits uptake of noradrenaline and 5-HT by synaptosomes from rat brain with IC50 values of 79 and 51 µM, respectively. It also inhibits human monoamine oxidase-A (MOA-A) and MOA-B with IC50 values of 25 and 61 µM, respectively, which is similar to, but slightly less effective than, values obtained with trans-resveratrol.