bt549

Tubulin inhibitor 8 is an inhibitor of tubulin and various cancer cell lines and inhibits tubulin polymerisation and K562 cell growth with an IC50 of 0.73 μM and 14 nM respectively.

PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.

WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)

Tubulin inhibitor 6 (iHAP1) is an inhibitor of tubulin and a potent inhibitor of multiple cancer cell lines.

Diacetylcercosporin, a perylenequinone produced by Cercospora and Septoria, exhibits diverse biological activities including inhibition of P. falciparum strains sensitive and resistant to chloroquine and L. donovani parasites (IC50 = 3.1 μM) in vitro. It shows cytotoxicity against SK-MEL, KB, BT549, and SK-OV-3 human cancer cell lines (IC50s = 4.8-8.7 μM) and acts as a phytotoxin, inhibiting the growth of lettuce and bentgrass at a concentration of 1.62 mM.

4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple-negative breast cancer cell lines [MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549] at 50-100 μM but increases the proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and dendritic cells with EC50 values of approximately 8-16 μM.