cbz-nh-peg8-c2-acid

Cbz-NH-PEG8-C2-acid is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Cbz-NH-PEG12-C2-acid is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands to form PROTAC molecules, thereby enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Cbz-NH-PEG5-CH2COOH is a PEG-based PROTAC linker used in PROTAC synthesis.

Fmoc-NH-PEG10-acid, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Boc-NH-C4-acid is a PROTAC linker of the Alkyl ether class, utilized in the synthesis of PROTAC1 for the degradation of EED, EZH2, and SUZ12 in [PRC2].

Cbz-NH-PEG3-CH2COOH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras).

Cbz-NH-PEG1-CH2COOH, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Cbz-NH-PEG1-CH2CH2COOH, a PEG-based PROTAC linker, can be utilized in PROTAC synthesis.

Cbz-NH-PEG2-CH2COOH is a PEG-based PROTAC linker [PROTACs] useful in PROTAC synthesis.

Cbz-NH-PEG10-CH2COOH is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG12-NH-C2-acid is a PEG-based linker for PROTACs, joining two essential ligands necessary for the formation of PROTAC molecules. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system [within cells].

Boc-NH-PEG3-sulfonic acid, a polyethylene glycol (PEG) derived linker, is utilized in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

N-(Azido-PEG3)-NH-PEG3-acid is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

(S,R,S)-AHPC-(C3-PEG)2-C6-Cl is a small molecule HaloPROTAC incorporating the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker, capable of inducing degradation of GFP-HaloTag7 in cell-based assays [1].

Thalidomide-NH-(CH2)2-NH2 TFA, an alkyl-modified derivative of Thalidomide, functions as a Cereblon ligand to recruit CRBN proteins and serves as a crucial intermediate in the synthesis of CRBN-based PROTAC molecules targeting the SHP2 protein.

Boc-NH-C6-amido-C4-acid (PROTAC Linker 32) is an alkyl ether-based linker widely used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Cbz-aminooxy-PEG8-acid is a PEG-based linker used in PROTACs to join two essential ligands, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Cbz-N-amido-PEG20-acid is a PEG-based linker for PROTACs [proteolysis-targeting chimeras] that connects two critical ligands essential for the formation of PROTAC molecules, facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

Cbz-NH-PEG5-C2-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating selective protein degradation via the ubiquitin-proteasome system within cells.

Cbz-NH-PEG36-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands vital for PROTAC molecule formation. It enables selective protein degradation by utilizing the cell's ubiquitin-proteasome system.

Ph-Bis(C1-N-(C2-NH-Boc)2) is a versatile alkyl chain-derived linker used in the synthesis of PROTACs [1].

Cbz-NH-PEG3-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands crucial for PROTAC molecule formation. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

NH-bis(PEG3-acid) is a PEG-based linker utilized in PROTACs, connecting two essential ligands crucial for creating PROTAC molecules. This linker leverages the ubiquitin-proteasome system within cells to enable selective protein degradation.

DNP-NH-PEG2-C2-acid is a PEG-based linker for PROTACs, which connects two essential ligands critical for PROTAC molecule formation, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Boc-NH-PEG2-C2-amido-C4-acid (PROTAC Linker 30) is a polyethylene glycol (PEG)-based linker used in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

Boc-NH-PEG7-acid, a PEG-based linker for PROTACs, connects two essential ligands crucial for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

2-Bromo-22-dimethyl-acetamido-PEG3-acid is a polyethylene glycol (PEG) derivative commonly used as a PEG-based PROTAC linker in PROTAC synthesis [1].

Thalidomide-NH-CBP p300 ligand 2 (P-007) is a PROTAC-based compound engineered to degrade the proteins CBP and p300, functioning as a molecular antagonist (WO2020173440).

1-Cbz-azetidine-3-carboxylic acid (catalog number: T66609, CAS number: 97628-92-7) is a valuable organic compound for life sciences research.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthetic conjugate that combines a Thalidomide-based cereblon ligand and a linker, commonly utilized in PROTAC technology. This compound serves as a connector between the target protein and the E3 ligase, facilitating targeted protein degradation.

DSPE-PEG-2-Aminoethyl-alpha-mannopyranoside (MW 2000) is a polyethylene glycol (PEG) derived linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

NH-bis(PEG2-C2-acid) is a PEG-based linker essential for PROTACs, facilitating the conjugation of two critical ligands and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl ether-based PROTAC linker used for synthesizing PROTACs [1].

2-(Biotin-amido)-13-bis(carboxylethoxy)propane is a polyethylene glycol (PEG)-based PROteolysis TArgeting Chimera (PROTAC) linker used in the synthesis of PROTACs[1].

N-Fmoc-8-aminooctanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. N-Fmoc-8-aminooctanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Boc-NH-PEG-amine (MW 5000) is a PEG-based PROTAC linker used for the synthesis of PROTACs [1].

3-(2-Pyridyldithio)propanoic Acid is an alkyl chain-derived PROTAC linker used for synthesizing PROTACs [1].

Cbz-NH-PEG2-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two key ligands essential for PROTAC molecule formation, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-NH-PEG1-C2-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for forming PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system in cells.

Boc-NH-ethyl-SS-propionic acid, an ADC linker compound, is utilized for the synthesis of antibody-drug conjugates (ADCs)[1].

Fmoc-NH-ethyl-SS-propionic acid is a cleavable linker compound used in the synthesis of antibody-drug conjugates (ADCs)[1].

N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid is a polyethylene glycol (PEG)-based linker used in the development of proteolysis targeting chimeras (PROTACs)[1].

Boc-NH-PEG-amine (MW 3400) is a PEG-based PROTAC linker used in PROTAC synthesis[1].

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

(2-Pyridyldithio)-PEG4 acid is a four-unit cleavable polyethylene glycol (PEG) linker specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1]. It serves as a crucial component in the conjugation of antibodies and drugs, enabling targeted drug delivery and enhanced therapeutic efficacy. This linker possesses a (2-pyridyldithio) group at one end, facilitating the attachment of the linker to the specific site on the antibody molecule. The PEG4 chain provides the necessary flexibility and biocompatibility for optimal drug release while maintaining stability throughout the circulation in the body. Ultimately, (2-Pyridyldithio)-PEG4 acid is instrumental in the development and advancement of ADCs, a promising approach in cancer therapy.

Fmoc-NH-pentanoic acid-NHS-SO3Na is a PROTAC linker molecule derived from an alkyl chain, facilitating the synthesis of PROTACs[1].

Cbz-N-PEG10-acid is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Cbz-NH-PEG24-C2-acid is a PEG-based linker for PROTACs that enables selective protein degradation by linking two essential ligands, crucial for forming PROTAC molecules, and leveraging the ubiquitin-proteasome system within cells.