cdk12 in 3

CDK12-IN-3 is a selective and potent CDK12 inhibitor with anti-tumor activity, which can be used to study malignant tumors.

3X FLAG peptide TFA (402750-12-3 free base) (3X FLAG peptide TFA) is a synthetic peptide of 23 amino acid residue. The Asp-Tyr-Lys-Xaa-Xaa-Asp motif is repeated three times in the peptide.

CDK HDAC-IN-3 is an orally active dual inhibitor of HDACs and CDKs, offering potent and selective inhibition of CDK9, CDK12, CDK13, HDAC1, HDAC2, and HDAC3, with IC50 values of 98.32 nM, 98.85 nM, 100 nM, 62.12 nM, 93.28 nM, and 82.87 nM, respectively, and is applicable in the treatment of acute myeloid leukemia (AML) [1].

Zwittergent 3-12 Detergent is a useful organic compound for research related to life sciences. The catalog number is T65355 and the CAS number is 14933-08-5.

(3β)-3-Hydroxyoleanan-12-one (compound 23), a natural product, is isolated from Codonopsis ovata [1].

9(11),12-Oleanadien-3-ol is a natural product from Euonymus maackii.

6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid is a natural product for research related to life sciences. The catalog number is TN3143 and the CAS number is 194027-11-7.

22-Hydroxy-3-oxoolean-12-en-29-oic acid is a useful organic compound for research related to life sciences and the catalog number is T125847.

3(Z),6(Z),9(Z),12(Z),15(Z)-Octadecapentaenoic acid, a microalgal polyunsaturated fatty acid (PUFA), is identified in G. kowalevskii and serves as a chemotaxonomic biomarker for microalgae and dinoflagellates.

22-Hydroxy-3-oxo-12-ursen-30-oic acid is a natural product for research related to life sciences. The catalog number is TN2812 and the CAS number is 173991-81-6.

3-Hydroxy-12-oleanene-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2937 and the CAS number is 226562-47-6.

Lup-12-en-3-ol, (3beta,18beta,19beta)- is a bioactive chemical.

3-Hydroxy-12-oleanene-27,28-dioic acid, 3-O-(6-Deo is a useful organic compound for research related to life sciences. The catalog number is T126383 and the CAS number is 111665-41-9.

3-hydroxy-12-oxochol-9(11)-en-24-oic acid is a useful organic compound for research related to life sciences and the catalog number is T131562.

28-Hydroxy-3-oxoolean-12-en-29-oic acid is a natural product for research related to life sciences. The catalog number is TMA1182 and the CAS number is 381691-22-1.

(6S,9S,12S)-Benzyl 12-benzyl-9-isobutyl-2,2-dimethyl-4,7,10-trioxo-6-phenethyl-3-oxa-5,8,11-triazatridecan-13-oate is a useful organic compound for research related to life sciences. The catalog number is T66648 and the CAS number is 868540-15-2.

'(12β)-20-(β-D-Glucopyranosyloxy)-12-hydroxydammar-24-en-3-one is a naturally occurring compound isolated from Cladosporium microorganisms [1].'

Tenacigenin B, a component of the plant Poria cocos, is identified as 3-O-β-Allopyranosyl-(1→4).

2alpha,19alpha-Dihydroxy-3-oxo-urs-12-en-28-oic acid has anti-HIV activity. It shows an inhibitory effect on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and causes a significant delay o

1-Palmitoyl-2-12-PAHSA-3-oleoyl-sn-glycerol, an endogenous triacylglycerol, comprises palmitic acid (at the sn-1 position), the fatty acid ester of hydroxy fatty acids (FAHFA), 12-PAHSA (at the sn-2 position), and oleic acid (at the sn-3 position). Identified in the lipid extract of mouse adipose tissue, this triacylglycerol demonstrates that levels of FAHFA-containing triacylglycerols are over 100-fold higher than those of non-esterified FAHFAs, suggesting their role as intracellular storage reservoirs for FAHFAs.

CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].

CDK7 12-IN-1 is a selective inhibitor of CDK7 (IC50: 3 nM) and CDK12 (IC50: 277 nM) and effectively inhibits tumor growth.