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By Target- Apoptosis
- PDGFR(1)
- VEGFR(1)
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Results for "
cgp 797870 dihydrochloride
" in TargetMol Product Catalog- Inhibitors & Agonists2
Vatalanib dihydrochloride
CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride
T6720212141-51-0
Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2 KDR. It exhibits less effective against VEGFR1 Flt-1 and 18-fold against VEGFR3 Flt-4.
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CGP 74514 dihydrochloride
T36349
Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002. Yu et al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822 PMID:12702569 |Furet et al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403 PMID:10896313
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