contraception

Ulipristal acetate (CDB-2914) is an orally bioavailable, acetate salt of ulipristal, a selective progesterone receptor modulator with anti-progesterone activity. Ulipristal binds to the progesterone receptor (PR), thereby inhibiting PR-mediated gene expression, and interfering with progesterone activity in the reproductive system. As a result, this agent may suppress the growth of uterine leiomyomatosis. Furthermore, by inhibiting or delaying ovulation and effecting endometrial tissue, ulipristal can be used as an emergency contraception.

Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.

Org-33628, a progesterone receptor antagonist, is used potentially for female contraception.

ALK inhibitor 1 is a selective ALK kinase inhibitor.

Gamendazole is a novel drug candidate for male contraception. It has been shown to reduce fertility in male rats without affecting testosterone levels.

BET Bromodomain Inhibitor 3 is a BET bromodomain inhibitor with an inhibitory Ki value of >40 µM against BrdT. It is utilized in research related to contraception, cancer, and heart disease [1].

Testosterone undecanoate is a metabolite of Testosterone, which is a promising androgen for male hormonal contraception.

Ulipristal is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

Norethindrone-2,2,4,6,6,10-d6 is a deuterated compound of Norethindrone. Norethindrone has a CAS number of 68-22-4. Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.

Norethindrone (Ethynyl-13C2) is the 13C labeled compound of Norethindrone. Norethindrone has a CAS number of 68-22-4. Norethindrone is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.

Etonogestrel (Implanon) is a steroidal progestin used as hormonal contraceptives.

Org-31710 is a progesterone receptor antagonist potentially for contraception.

Norgestrel (WY-3707) is a synthetic progestin commonly used alone or in combination with an estrogen for contraception. Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes.

ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.