dbco nhco peg6 biotin

DBCO-NHCO-PEG6-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG6-Boc (Biotin-PEG6-t-butyl ester) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

N-(DBCO-PEG4)-N-Biotin-PEG4-NHS is a PEG-based PROTAC linker suitable for synthesizing PROTACs[1].

TAMRA-Azide-PEG-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-Amide-PEG5-acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.

DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker.

Biotin-PEG-amine (MW 2000) is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

DBCO-NHCO-PEG12-maleimide is a PEG-based PROTAC linker utilized in the synthesis of PROTACs[1].

β-Estradiol-6-CMO-PEG3-biotin serves as a cleavable 3-unit PEG ADC linker for the synthesis of antibody-drug conjugates (ADCs)[1].

Dde Biotin-PEG4-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG13-NHS ester is a pegylated PROteolysis-TArgeting Chimera (PROTAC) linker, serving as a valuable tool for PROTAC synthesis[1].

DBCO-NHCO-PEG13-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Diazo Biotin-PEG3-DBCO is a cleavable three-unit polyethylene glycol (PEG) linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NHCO-PEG7-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Biotin-PEG-triethoxysilane (MW 2000) is a polyethylene glycol (PEG) derivative functionalized with triethoxysilane and biotin moieties. This compound serves as a PEG-based linker for PROTAC synthesis, facilitating the targeted degradation of proteins of interest.

DBCO-NHCO-PEG12-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-Biotin (Azadibenzocyclooctyne-Biotin conjugate) is a PROTAC linker based on the alkyl chain.

Biotin-PEG6-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DSPE-PEG-Biotin (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

Biotin-PEG6-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Biotin-PEG-triethoxysilane (MW 5000) is a PEG-based PROTAC linker utilized for PROTAC synthesis[1].

PC DBCO-PEG3-biotin is a trimeric polyethylene glycol (PEG) linker, specifically designed for antibody-drug conjugate (ADC) synthesis, with a cleavable moiety consisting of a dibenzocyclooctyne (DBCO) group and a biotin molecule. This linker provides a platform for the efficient attachment of drugs to antibodies, facilitating the targeted delivery and controlled release of therapeutic agents in ADCs[1].

Biotin-PEG-amine (MW 3400) is a polyethylene glycol (PEG)-based linker compound utilized for PROTAC synthesis [1].

m-PEG6-(CH2)6-Phosphonic acid serves as a PEG-based PROTAC linker for synthesizing PROTACs[1].

Biotin-PEG-Biotin (MW 1000) is a PEG-derived PROTAC linker employed in PROTAC synthesis[1].

DBCO-NHCO-PEG2-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG3-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-SS-PEG4-Biotin is a cleavable link mid-functional ADC linker composed of a 4-unit PEG moiety. It finds utility in the synthesis of antibody-drug conjugates (ADCs)[1].

Biotin-PEG6-azide (Biotin-PEG6-N3) is a biotin-labeled, PEG-based PROTAC linker that can be used in PROTAC synthesis.

DBCO-NHCO-PEG2-NHS ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

Biotin-PEG6-Thalidomide is a PROTAC linker based on PEG.

Biotin-PEG6-Mal is a biotinylated PROTAC linker derived from a polyethylene glycol (PEG) scaffold. It serves as an essential component for the synthesis of PROTACs, which are targeted protein degraders[1].

Biotin-PEG6-alcohol is a PEG-based PROTAC linker containing a biotin label. This compound serves as a key component in the synthesis of PROTACs, facilitating the conjugation of target-recruiting moiety and E3 ligase-recruiting moiety [1].

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].

DBCO-NHCO-PEG2-maleimide is a polyethylene glycol (PEG) derived PROTAC linker utilized during PROTAC synthesis[1].

DBCO-NHCO-S-S-NHS ester is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NHCO-C4-NHS ester is an alkyl chain-derived PROTAC linker applicable for PROTACs synthesis[1].

DBCO-NHCO-PEG6-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG12-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-Sulfo-Link-biotin is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs) [1].

Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker utilized for PROTACs synthesis[1].

Biotin-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

WSPC Biotin-PEG3-DBCO is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

(+)-Biotin-PEG6-hydrazide is a polyethylene glycol (PEG) derived linker, specifically designed for the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-NHCO-PEG3-Fmoc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG2-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG2-Biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.