dbco ss amine

DBCO-SS-amine is a cleavable linker essential in ADC synthesis, facilitating the attachment of cytotoxic drugs to antibodies for targeted delivery to cells or proteins. Its cleavable nature allows for controlled drug release, enhancing the effectiveness of ADCs (antibody-drug conjugates).

DBCO-amine is a cleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG3-amine, a PEG-based linker for PROTACs, joins two essential ligands and facilitates the formation of PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG9-amine is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tetrazine-PEG5-SS-amine, a cleavable 5-unit polyethylene glycol (PEG) linker, is utilized in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-C2-PEG4-amine, a PEG-based linker for PROTACs, connects two essential ligands necessary for forming PROTAC molecules. This linker facilitates selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively) [1].

DBCO-PEG4-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). DBCO-PEG4-amine can be used in the synthesis of FPM-PEG4-DBCO (a homobifunctional azide-to-azide cross-linker)[1].

DBCO-C3-PEG4-amine is a PEG-based linker for PROTACs that joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG12-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system (within cells).

DBCO-NHCO-PEG6-amine is a PEG-based linker used in PROTACs that joins two essential ligands for PROTAC molecule formation, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG2-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Sulfo DBCO-amine, an alkyl chain-derived PROTAC linker, is utilized for synthesizing PROTACs [1].

DBCO-PEG6-amine is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules [DBCO-PEG6-amine]. It enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

TCO-SS-amine, a cleavable linker crucial in ADC synthesis, joins cytotoxic drugs to antibodies for precise delivery to target cells or proteins. Its cleavable nature ensures controlled drug release, optimizing the effectiveness of ADCs.

DBCO-SS-aldehyde is an ADC linker employed for ADC synthesis[1]. This cleavable linker is designed to facilitate the conjugation of antibodies and drugs, resulting in antibody-drug conjugates (ADCs).

DBCO-PEG1-amine is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-NHCO-PEG2-amine is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-PEG4-SS-TCO is a cleavable 4-unit polyethylene glycol (PEG) linker crucial for the synthesis of antibody-drug conjugates (ADCs)[1], facilitating the connection of the drug payload to the antibody and enabling targeted drug delivery.

BCN-SS-amine is a cleavable linker essential in the synthesis of antibody-drug conjugates (ADC). It connects cytotoxic drugs to antibodies, allowing for precise delivery to targeted cells or proteins. The cleavable nature ensures controlled drug release, thereby optimizing the effectiveness of ADCs.

Sulfo DBCO-PEG4-amine is a PEG-based linker for PROTACs, connecting two essential ligands crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

DBCO-SS-PEG4-Biotin, a cleavable, mid-functional ADC linker with a 4-unit PEG moiety, is used in the synthesis of antibody-drug conjugates (ADCs)[1].