dna vaccines

DMG-PEG 2000 (DMG-PEG2000) is a lipid excipient that has been used in combination with other lipids in the formation of lipid nanoparticles. Formulations containing DMG-PEG 2000 have been used in the development of lipid nanoparticles for the delivery of mRNA-based vaccines.

ODN 1982, an unmethylated oligodeoxyribonucleotide (ODN) lacking a CpG motif, serves as a key component in the preparation of DNA vaccines. This compound effectively inhibits R-848 signaling. Its sequence is denoted as 5'-tccaggacttctctcaggtt-3' [1] [2].

SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv

DSPE-PEG-NHS (MW 3400), a pegylated phospholipid derivative, is utilized in the formulation of liposomes or lipid nanoparticles within targeted drug delivery systems, including DNA or mRNA vaccines.