ea 1

1. Dehydroabietic acid (Dehydroabietate) (DAA) is an EBV-EA activation inhibitor. 2. DAA is a useful food-derived compound for treating obesity-related diseases, by decreasing plasma glucose, insulin levels, plasma triglyceride (TG) , and hepatic TG levels. 3. DAA derivatives displays anti-secretory and anti-pepsin effect in animal models.

11-Oxomogroside II A1 (compound 7), an oxidized cucurbitin derived from the ethanol extract of Rohanberry fruit, inhibits the activation of Epstein-Barr virus (EBV) early antigen (EBV-EA) induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) and modestly inhibits the activation of (±)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor [1].

(24xi)-24,25-Dihydroxycycloartan-3-one exhibits inhibitory effects on both EBV-EA and NOR 1 activation.

Methyl lucidenate Q, a variant of methyl lucidenate, exhibits potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induction [1].

Cabenoside D (compound 8), a triterpenoid glycoside derived from the methanol extract of lichen root, exhibits anti-inflammatory activity. It effectively inhibits inflammation and the activation of early Epstein-Barr virus antigen (EBV-EA) induced by 12-O-tetracylacyl hormone-13-acetate (TPA) in mice [1].

(24R)-Cycloart-25-ene-3beta,24-diol may be an anti-tumor promoter, it exhibits inhibitory effects on both Epstein-Barr virus early antigen (EBV-EA) and (+ -)-(E)-methtyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3- hexemide (NOR 1) activation.

11-Oxomogroside IIa is a cucurbitane glycoside extracted from the fruits of Siraitia grosVenorii. It has inhibitory effects against the EBV-EA activation induced by TPA, shows weak inhibitory effects on activation of NOR 1, a nitric oxide (NO) donor.

Capsorubin is a carotenoid with a variety of biological activities. capsorubin inhibited lipid peroxidation induced by 2,2′-azino(2,4-dimethylvaleronitrile) (AMVN) at a concentration of 167 μM. capsorubin (1 μM) reduced uvb-induced DNA strand breaks and apoptosis in human dermal fibroblasts. formation. It also inhibited the activation of ebvirus early antigen (EBV-EA) induced by 12-carnosine 13-acetate fobo in Raji cells.