fludarabine

Fludarabine (Fludarabinum) is a fluorinated purine analog, an inhibitor of nucleic acid synthesis and an inhibitor of STAT1 activation. Fludarabine has antitumor activity and can be used for the treatment of leukemia and lymphoma.

Fludarabine Phosphate (NSC 312887 Phosphate) is the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase, and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.

Fludarabine triphosphate (F-ara-ATP) trisodium, the principal metabolite of Fludarabine, is a potent, noncompetitive, and specific inhibitor of DNA primase with an IC50 value of 2.3 μM and a Ki of 6.1 μM. It obstructs DNA synthesis by hindering DNA primase and primer RNA formation, while also inhibiting ribonucleotide reductase and DNA polymerase activities, effectively inducing cellular apoptosis [1] [2].

Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate, inhibits ribonucleotide reductase and DNA polymerase, ultimately leading to cellular apoptosis.

Fludarabine-Cl shows inhibition effect on RNA adenosine deaminase 1(ADAR1) that can be used for preventing and/or treating diseases related with cancer or tumor [1].

2'-O-Methyladenosine 5'-monophosphate triethyl ammonium is an adenosine analog that primarily functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. Its notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2-Amino-3’,5’-di-O-acetyl-N6,N6-dimethyl-2’-O-methyladenosine is an adenosine analog, known for primarily acting as a smooth muscle vasodilator and for inhibiting cancer progression. Its popular products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3’-Beta-C-Methyl-N6-isopentenyl adenosine, an adenosine analog, primarily acts as a smooth muscle vasodilator and has shown potential in inhibiting cancer progression. Popular products in this category include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-Isopentenyladenine is an adenosine analog that primarily functions as a smooth muscle vasodilator and has been shown to inhibit cancer progression. Notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3’-Beta-C-ethynyl-N6-(m-trifluoromethyl benzyl)adenosine is an adenosine analog. Adenosine analogs primarily act as smooth muscle vasodilators and have also demonstrated inhibition of cancer progression. Notable related compounds include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

2-Diethoxymethyl adenosine is an adenosine analog primarily acting as a smooth muscle vasodilator and inhibiting cancer progression. Notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog, primarily acting as a smooth muscle vasodilator and inhibiting cancer progression. Popular products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

1-(β-D-Xylofuranosyl)-N6-(m-trifluoromethylbenzyl)adenine is an adenosine analog that predominantly functions as a smooth muscle vasodilator and has been shown to inhibit cancer progression. Its notable products include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].

3’-Beta-C-ethynyl-N6-iso-pentenyl adenosine is an adenosine analog that primarily functions as a smooth muscle vasodilator and has demonstrated potential in inhibiting cancer progression. Its notable derivatives include adenosine phosphate, Acadesine, Clofarabine, Fludarabine phosphate, and Vidarabine [1].