ganoderic acid b

Ganoderic acid B is a chemical marker in quality control of G. lucidum and related products. Ganoderic acid B-containing herbs has potential influence towards therapeutic window of trifluoperazine.Ganoderic acid B has antinociceptive effect

Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1].

Aristolochic acid B (Aristolochic Acid II) is one of the major components of the carcinogenic plant extract aristolochic acid, is known to be mutagenic and to form DNA adducts in vitro and in vivo, Aristolochic acid B shows more carcinogenic risk than aristolochic acid I, and this may be, at least partly, the result of its increased levels in kidney and plasma.

Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect

1. Ganoderic acid D is one of the major components in Ganoderma triterpenes. 2. Ganoderic acid D treatment for 48h inhibits the proliferation of HeLa human cervical carcinoma cells with an IC(5) value of 17.3 +/- .3 microM.

A novel combination of triterpenoids includes at least ganoderic acid S (GAS), ganoderic acid T (GAT), ganoderic acid Me (GAMe), ganoderic acid R (GAR), and ganodermic acid S (GMAS), the composition is suitable for the treatment or prophylaxis of colon ca

Ganoderic acid GS-2 inhibits the activity of the human immunodeficiency virus-1 (HIV-1) protease.

Ganoderic acid T1, a deacetylated derivative of Ganoderic acid T, diminishes mitochondrial membrane potential and triggers cell apoptosis by activating caspase-9 and caspase-3, thus impairing the antioxidant defense system of cancer cells. Additionally, it elevates intracellular ROS levels, yielding pro-oxidant activities and cytotoxicity [1].

Ganoderic acid Df, a lanostane-type triterpenoid isolated from the fruiting body of Ganoderma lucidum, potently inhibits aldose reductase with an IC 50 of 22.8 ± 0.6 μM [1].

Ganoderic acid T-Q and TR are two inhibitors of H5N1 and H1N1 NAs.

Ganoderic acid K is an angiotensin-converting enzyme inhibitor. It has anti-tumor, and anti-inflammatory activities.

Ganoderic acid T, a natural compound isolated from Ganoderma lucidum [1], exhibits various pharmacological properties.

Ganoderic acid Me, a triterpenoid present in Ganoderma lucidum [1], exhibits various biological activities.

Ganoderic acid Mk (GA-Mk), a triterpenoid acid derived from Ganoderma lucidum mycelia, exhibits potent anti-proliferative properties and can induce apoptosis in HeLa cells through a mitochondria-mediated pathway, making it significant for cervical cancer research [1] [2].

The binding affinities of ganoderic acid DM and ganoderic acid Z (ΔGbind, -16.83 and-10.99 kcal mol-1) are comparable to that of current commercial drug oseltamivir (-23.62 kcal mol-1);Ganoderic acid DM is a potential source of anti-influenza ingredient, with novel binding pattern and advantage over oseltamivir, it has steric hindrance on the 150 cavity of N1 protein, and exerts activities across the H274Y and N294S mutations, is the attractive candidates of novel neuraminidase (NA) inhibitors.Ganoderic acid zeta has cytotoxicity in vitro against Meth-A and LLC cell lines.

Ganoderic acid ε, a naturally occurring terpenoid, is extracted from the Fungus Ganoderma lucidum. This compound possesses an ED 50 value of 12.2 μg/mL, as demonstrated in its impact on Meth-A tumor cells.

Ganoderic acid AM1 treatment for 48 h inhibited the proliferation of HeLa human cervical carcinoma cells with IC(50) values of 19.8+/-0.7 microM.

Ganoderic acid SZ is a natural product. The catalog number is TN4104 and the CAS number is 865543-37-9. Ganoderic acid SZ can be used as a reference standard.

Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane pr

Isosalvianolic acid B is a natural from Salviae miltiorrhizae

Siraitic Acid B is a natural product(cucurbitane triterpenoid) isolated from the root of S. grosvenori .

Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.

Ganoderic acid Mf, an antitumor triterpenoid, selectively induces apoptosis in cancer cells through a mitochondria-mediated pathway while demonstrating high selectivity between normal and cancer cells. It also arrests the cell cycle in the G1 phase [1].

Ganoderic acid TN is a natural product. The catalog number is TN4106 and the CAS number is 112430-64-5. Ganoderic acid TN can be used as a reference standard.

Gambogic acid B, isolated from Garcinia hanburyi resin, exhibits cytotoxic effects on A549, HCT116, and MDA-MB-231 cell lines with respective IC50 values of 1.60 µM, 6.88 µM, and 0.87 µM [1].

Ganoderic acid L is a natural product from the fruiting body of the fungus Ganoderma lucidum (Reishi).

Gardenolic acid B shows promising hepatoprotective effects on nitrofurantoin-induced cytotoxicity in human liver-derived Hep G2 cells. Gardenolic acid B shows significant effects on terminating early pregnancy in rats.

Ganoderic acid Y significantly inhibits the replication of the viral RNA (vRNA) of EV71 replication through blocking EV71 uncoating.

Ganoderenic acid B, a natural product derived from Ganoderma lucidum, can work by inhibiting the transport function of ABCB1 and enhancing the cytotoxicity of chemotherapy drugs against AbCB1-mediated multidrug resistant cancer cells.

Ganoderic acid J, a natural terpenoid extracted from Ganoderma lucidum fungus, exhibits anti-inflammatory properties.

23S-hydroxy-11,15-dioxo-ganoderic acid DM is a natural product

Ganoderic acid D2 is a natural product

Deacetyl ganoderic acid F (DeGA F), a triterpenoid extracted from Ganoderma lucidum, inhibits lipopolysaccharide (LPS)-induced inflammation in vitro and in vivo.

Demethoxydeacetoxypseudolaric acid B's the metabolic reaction of TDA in vivo is mainly occurred in blood and contributes to be the hydrolysis of plasma esterase to ester bond, as well as the glucosylation reaction.

Ganoderic acid GS-1, an extensively oxygenated lanostane-type triterpenoid, exhibits anti-HIV-1 protease activities, displaying an IC50 value of 58 μM [1].

Ganoderic acid F has anti-hepatitis B, anti-inflammatory, and anti-tumor-promoting activities.

Myriceric acid B is a potent HIV-1 entry inhibitor targeting gp41 and can serve as a lead compound for developing novel anti-HIV-1 drug. Myriceric acid B scavenges DPPH free radicals with IC50 value of 21.8 uM, it inhibits aromatase activity with IC50 val

Poricoic acid B shows inhibitory activity against TPA-induced ear inflammatory oedema, it also shows potent inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)

Pseudolaric acid B β-D-glucoside (Pseudolaric acid B-glucopyranoside) is a natural product from Pseudolarix amabilis.

Adenostemmoic acid B is a natural product for research related to life sciences. The catalog number is TN6169 and the CAS number is 130217-16-2.

23-Dihydroganoderic Acid N has anticancer effects.

(S)-b-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of valine and thymine.

Ganolucidic acids B demonstrated the ability to induce hPXR-mediated CYP3A4 expression.

Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4.

Lucidenic acid B (Lucidenicacid B), a natural compound extracted from Ganoderma lucidum, induces activation of caspase-9 and caspase-3 and cleavage of PARP, which can induce apoptosis in human leukemia cells through mitochondrial mediation. Lucidenic acid B inhibits PMA-induced invasion of human hepatocellular carcinoma cells by inactivating the MAPK/ERK signaling pathway and decreasing the binding activity of NF-kappaB and AP-1. Lucidenic acid B had no effect on cell cycle and necrotic cells.

Ganoderic acid G is isolated from the surface of Ganoderma lucidum tube layer.