hioc

Selective TrkB receptor agonist. Protects neurons from excitotoxicity. Protects retinas from light-induced retinal degeneration (LIRD) in vivo. Blood brain barrier and blood-retinal barrier penetrant.

D-alpha-Methylbenzyl isothiocyanate is an antioxidant. It induces phase II enzyme activity and is also used as a chiral agent.

Thioctamide (Thioctic acid amide) is a trivial name for 6, 8-dithiooctanoic amide. It is 6, 8-dithiooctanoic acid's functional form where the carboxyl group is attached to protein (or any other amine) by an amide linkage (containing -NH2).

Butyl isothiocyanate is an isothiocyanate having a butyl group attached to the nitrogen. It has a role as a hapten.

Diethyldithiocarbamic acid copper salt is a chelating agent used in various metal, protein, and enzyme experiments. It can also serve as a complexing agent for synthesizing various organic compounds, including heterocyclic compounds, and as an inducer for copper-mediated cell death.

Pyrrolidinedithiocarbamate ammonium (1-Pyrrolidinedithiocarboxylic acid ammonium salt), a selective NF-κB inhibitor, inhibits translation of nitric oxide synthase mRNA to prevent induction.

L-Lysine thioctate is a lipoamidase substrate.

8-Methylsulfinyloctyl isothiocyanate is a compound with antimicrobial activity and notable inhibitory effects on plant growth. It also exhibits COX-2-mediated inflammatory response impairment in LPS-stimulated raw macrophages.

Thiocystine can be produced in the hydrolysis of proteins.

Thiocoraline is a depsipeptide and DNAbis-intercalator originally isolated fromMicromonosporawith antibacterial and anticancer activities.1,2It is active against the Gram-positive bacteriaS. aureus,B. subtilis, andM. luteus(MICs = 0.05, 0.05, and 0.03 μg/ml, respectively) but not Gram-negativeE. coli,K. pneumoniae, orP. aeruginosa(MICs = >100 μg/ml for all).1Thiocoraline inhibits RNA and DNA polymerase and thymidylate synthase (IC50s = 6, 6, and 15 μg/ml, respectively), as well as RNA and DNA synthesisin vitro(IC50s = 0.008 and 0.4 μg/ml, respectively). It is cytotoxic to P388, A549, HT-29, and MEL-28 cancer cells (IC50s = 0.002, 0.002, 0.01, and 0.002 μg/ml, respectively). 1.Romero, F., Espilego, F., Pérez Baz, J., et al.Thiocoraline, a new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activitiesJ. Antibiot. (Tokyo)50(9)734-737(1997) 2.Negri, A., Marco, E., García-Hernández, V., et al.Antitumor activity, X-ray crystal structure, and DNA binding properties of thiocoraline A, a natural bisintercalating thiodepsipeptideJ. Med. Chem.50(14)3322-3333(2007)

S-(N-Methylsulfinylbutylthiocarbamoyl)-L-cysteine (SFN-Cys) is an isothiocyanate derivative, functioning as an active metabolite of sulforaphane, a class I and II histone deacetylase (HDAC) inhibitor, and anticancer agent. This compound is generated from sulforaphane through intermediates - DL-sulforaphane glutathione and sulforaphane cysteinylglycine - via the mercapturic acid pathway enzymes. At a concentration of 20 µM, SFN-Cys diminishes invasion and migration of U87MG and U373 MG glioblastoma cells as observed in wound healing and chamber assays. Furthermore, at 45 µM, it significantly lowers the expression of α-tubulin, βIII-tubulin, stathmin 1, and X-linked inhibitor of apoptosis (XIAP), and also reduces cell density in paclitaxel-resistant A549 lung cancer cells (A549/T). Additionally, when used at 30 µM, SFN-Cys prompts apoptosis and cell cycle arrest at the G2/M phase in U87MG and U373 MG cells.

Methiocarb, a carbamate pesticide, is used as an insecticide, acaricide, bird repellent, and molluscicide. Methiocarb stimulates cholinergic by inhibiting reversibly acetylcholinesterase activity, making methiocarb a potent neurotoxin.

Pterostilbene-isothiocyanate (PTER-ITC) demonstrates strong anticancer properties in vitro, particularly disrupting the interaction between β-catenin and TCF-4 in human osteosarcoma cells [1].

Geninthiocin A is a cyclic thiopeptide bacterial metabolite originally isolated from Streptomyces sp. DD84. It is active against a variety of Gram-positive bacteria (MICs = 0.2-4 μg/ml), the Gram-negative bacterium C. violaceum (MIC = 19 μg/ml), and the fungus M. hiemalis (MIC = 38 μg/ml). Geninthiocin A also induces tipA promoter transcription with a minimum induction concentration of 1.2 ng/ml.

1-Isothiocyanato-PEG3-azide is a PEG-based PROTAC linker utilized for PROTAC synthesis[1].

Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram .1It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2Methyl diethyldithiocarbamate inhibits liver low Kmaldehyde dehydrogenase (ALDH) in rats (ID50= 15.5 mg/kg).1It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg. 1.Hart, B.W., Yourick, J.J., and Faiman, M.D.S-methyl-N,N-diethylthiolcarbamate: A disulfiram metabolite and potent rat liver mitochondrial low Km aldehyde dehydrogenase inhibitorAlcohol7(2)165-169(1990) 2.Gessner, T., and Jakubowski, M.Diethyldithiocarbamic acid methyl ester. A metabolite of disulfiramBiochem. Pharmacol.21(2)219-230(1972)

Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 µg/ml. [1] [2] At concentrations of 10 µM, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drugs. Unlike INH and ETH, isoxyl also partially inhibits the synthesis of fatty acids. Isoxyl shows no acute toxicity against primary macrophage cell cultures as demonstrated by diminution of redox activity.[2]

Obidoxime thiocyanate is an AChE reactivator.

3-((((4-Amino-2-methylpyrimidin-5-yl)methyl)carbamothioyl)thio)-4-oxopentyl acetate is a useful organic compound for research related to life sciences and the catalog number is T67227.

S-(N-PhenethylthiocarbaMoyl)-L-cysteine (PEITC-Cys) is an anticarcinogenic agent. S-(N-PhenethylthiocarbaMoyl)-L-cysteine shows antileukemic activity which inhibits DNA synthesis in HL60 cells [1]. S-(N-PhenethylthiocarbaMoyl)-L-cysteine is an inhibitor of P450 [2].

Ophiocarpine is a protoberberine alkaloid.

Thioctoyl tripeptide-1 is a peptide.

Guanidine thiocyanate is a useful organic compound for research related to life sciences. The catalog number is T66809 and the CAS number is 593-84-0.

Benzyl isothiocyanate (Benzoylthiocarbimide) (BITC) is an isothiocyanate originally found in cruciferous vegetables. It shows immunomodulatory, anti-parasitic, antibiotic, antioxidative, anti-atherosclerotic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities.

Phenylethyl isothiocyanate (JC5411) is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.

Promothiocin A is an antibiotic.

Desferrithiocin is a more active iron chelator than desferrioxamine.

5-Methyl-4'-thiocytidine is a Nucleoside Derivative - Thio-nucleoside.

Thiochrome is a selective enhancer of M4 muscarinic receptor of acetylcholine (ACh) affinity.

Xylyl isothiocyanate is a biochemical.

Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .Erythromycin thiocyanate

Thiocysteine is a cysteine derivative, an activator of aminolevulinate synthetase, which is used in studies of cysteine metabolism. It is also an anti-tumor compound.

Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-oxidants and acetylcholinesterase inhibitors, that can be used for the treatment of Alzheimer's disease (AD).

4'-Thiocytidine is a Thio-nucleoside.

Decyl thiocyanate is a biochemical.

Thiocholesterol, a cholesteric liquid crystal (CLC), functions as a robust stabilizer for silver nanoparticles (SNPs) and plays a significant role in the synthesis of cationic lipids. Its applications extend to plasma membrane research and drug delivery, highlighting its versatility and importance in these fields [1] [2].

Prothioconazole (Proline 480 SC Fungicide) is a chiral triazole fungicide in plant pathogen control.

3-Phenylpropyl isothiocyanate exhibits a potent inhibitory effect on N-nitrosomethyl-benzylamine (NMBA) tumorigenesis, thereby displaying strong chemopreventive properties [1] [2].

Lactosyl isothiocyanate is used as an affinity label for hexose transporter.

Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.

4,6-Dimethoxy-2-isothiocyanatopyrimidine-d6 is a deuterated compound of 4,6-Dimethoxy-2-isothiocyanatopyrimidine. 4,6-Dimethoxy-2-isothiocyanatopyrimidine has a CAS number of 110860-38-3.

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

L-alpha-Methylbenzyl isothiocyanate is an antioxidant. It induces phase II enzyme activity and is also used as a chiral agent.

m-Cresol thiocyanate is a bioactive chemical.

Thiocillin I, a thiopeptide antibiotic, demonstrates potent in vitro antibacterial effects against Gram-positive bacteria. This compound exhibits minimum inhibitory concentrations (MICs) of 2 μg/mL, 0.5 μg/mL, 4 μg/mL, and 0.5 μg/mL against S. aureus 1974149, E. faecalis 1674621, B. subtilis ATCC 6633, and S. pyogenes 1744264, respectively.

2-Thiocytidine is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system and has a broad spectrum of antitumor activity.2-Thiocytidine induces apoptosis by inhibiting DNA synthesis.2-Thiocytidine is a purine nucleoside analog that targets malignant tumors of the inert lymphatic system.

Fenothiocarb is an agent of pesticide.

DL-alpha-Methylbenzyl isothiocyanate is an antioxidant used to induce phase II enzyme activity.

3-Iodophenylisothiocyanate is a bioactive chemical.

Decane, 1-isothiocyanato- is a biochemical.