hydroxy-peg3-ss-peg3-alcohol

Hydroxy-PEG3-SS-PEG3-alcohol is a 6 unit polyethylene glycol (PEG) linker that can be cleaved. It is commonly employed in the synthesis of antibody-drug conjugates (ADCs) [1].

DSPE-PEG-OH (MW 2000) is a PEG-based PROTAC linker for PROTAC synthesis.

2-(2,6-dioxopiperidin-3-yl)-4-((7-hydrox is protac.

AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.

Tri-GalNAc(OAc)3-Perfluorophenyl is a pentafluorophenyl-modified triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand utilized in the synthesis of GalNAc-lysosome-targeting chimeras (LYTACs). These chimeras facilitate targeted protein degradation through engagement with the asialoglycoprotein receptor [1].

m-PEG-NH2 (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC EGFR Degrader 3, a highly potent molecule, exhibits remarkable cellular activity against H1975 and HCC827 cells, maintaining high selectivity. It additionally reveals the lysosome's crucial role in the degradation mechanism of mutant EGFR [1].

(S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is a small molecule HaloPROTAC that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-(C3- PEG) 2- C6- Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1].

Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.

Azide-PEG-amine (MW 2000) is a Polyethylene Glycol (PEG) derived linker compound utilized in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].

PROTAC FLT-3 degrader 1 is a PROTAC FLT-3 degrader of internal tandem duplication (ITD)(IC50 0.6 nM),with anti-proliferative activity.

ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).

m-PEG-thiol (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Tri-GalNAc(OAc)3 TFA, a triantenerrary N-acetylgalactosamine (tri-GalNAc) ligand, is utilized in the synthesis of GalNAc-lysosome-targeting chimera (GalNAc-LYTAC). This compound facilitates targeted protein degradation by engaging with the asialoglycoprotein receptor [1].

TAMRA-Azide-PEG-biotin is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

HO-PEG-amine (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG-NH2 (MW 20000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC BTK Degrader-3 is a potent degrader of Bruton's tyrosine kinase (BTK), exhibiting a DC50 (median degradation concentration) of 10.9 nM in Mino cells. This compound shows promise for research into B-cell malignancies, such as chronic lymphoid malignancies [1].

DBCO-(PEG)3-VC-PAB-MMAE is a chemical compound where monomethyl auristatin E (MMAE), a potent tubulin inhibitor acting as a toxin payload in antibody-drug conjugates, is conjugated to a DBCO-(PEG)3-vc-PAB linker.

m-PEG-azide (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

PROTAC Bcl-xL degrader-3 is a potent ROTAC Bcl-xL degrader.

Biotin-PEG-amine (MW 2000) is a polyethylene glycol (PEG) derivative commonly employed as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

Amine-PEG-CH2COOH (MW 5000) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Amine-PEG-CH2COOH (MW 2000) is a polyethylene glycol (PEG) derivative employed as a linker in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

TSPO ligand-3, functioning as an AUTAC2 ligand, incorporates both a p-fluorobenzylguanine (FBnG) and a synthetic ligand of FKBP (SLF) moiety, leading to the substantial inhibition of FKBP12 in HeLa cells [1].

PROTAC IRAK4 Ligand-3 serves as a ligand for PROTAC IRAK4 Degrader-7 and is utilized in cancer research [1].

PROTAC BRD9 Degrader-3 is a bifunctional degrader targeting BRD9, utilized in cancer research.

Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker employed in PROTAC synthesis[1].

m-PEG-NH2 (MW 5000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG-mal (MW 2000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DSPE-PEG-Amine (MW 5000) is a polyethylene glycol (PEG)-based PROTAC linker. It serves as an essential PROTAC linker component in the synthesis of PROteolysis TArgeting Chimeras (PROTACs)[1].

m-PEG-NH2 (MW 1000) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Amine-PEG-amine (MW 3400) is a polyethylene glycol (PEG) -based linker used for synthesizing proteolysis-targeting chimeras (PROTACs)[1].

m-PEG-CH2COOH (MW 2000) is a PEG-based PROTAC linker, suitable for synthesizing PROTACs[1].

Acrylate-PEG-OH (MW 5000) is a Polyethylene Glycol (PEG)-based linker compound primarily utilized in PROTAC synthesis[1].

LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the CDK9 inhibitor, SNS 032, linked to a hydrophobic tag via a glycol linker. Notably, LL-K9-3 does not affect the degradation of other CDKs (CDK1, 2, 4, 5, 6, and 7). Tested in 22RV1 cells, it effectively reduces androgen receptor (AR) and cMyc expression by inducing the selective and synchronous degradation of CDK9 and cyclin T1.

3-Mercaptopropionic acid NHS ester is a useful organic compound for research related to life sciences and the catalog number is T64663.

Amine-PEG-thiol (MW 5000) is a polyethylene glycol (PEG) based PROTAC linker, primarily utilized for the synthesis of PROTACs[1].

Methyl 3-hydroxypropanoate is a PROTAC linker compound, which belongs to the alkyl/ether family. It is commonly employed in the synthesis of PROTACs.

PROTAC BET Degrader-3 is a potent degrader OF BET based on PROTAC.

Aminooxy-PEG-OH (MW 2000) serves as a PEG-based PROTAC linker for the synthesis of PROTACs[1].

Amine-PEG-CH2COOH (MW 3400) is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs)[1].

PROTAC SOS1 Degrader-3 is a potent agent specifically designed to target and degrade SOS1 via the ubiquitin-proteasome system [1].

m-PEG2-O-Ph-3-NH2 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Thiol-PEG-CH2COOH (MW 5000) is a Polyethylene glycol (PEG) derived link molecule, commonly utilized in the construction of PROTACs, which are bifunctional compounds designed for targeted protein degradation [1].

Amine-PEG-amine (MW 35000), a PEG-based PROTAC linker, is utilized for the synthesis of PROTACs[1].

Mal-PEG-mal (MW 3400) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

m-PEG-triethoxysilane (MW 2000) is a polyethylene glycol (PEG) based linker compound, specifically designed for the purpose of synthesizing proteolysis-targeting chimeras (PROTACs)[1].

Biotin-PEG-triethoxysilane (MW 1000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

m-PEG-Lys-NHS ester (MW 20000) is an alkyl/ether-based PROTAC linker commonly employed in PROTAC synthesis[1].