Search Result

Search Results for " infarct "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T15052	Dapansutrile		NOD-like Receptor (NLR) , NOD
	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.		NOD-like Receptor (NLR) , NOD
T2423	P7C3-A20		Others
	P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.		Others
T12870	SCH79797 dihydrochloride		Apoptosis , Others , Protease-activated Receptor
	SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.		Apoptosis , Others , Protease-activated Receptor
T19659	Annaosanchun	YC6,YC-6,YC 6	Others , AMPK
	Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS).		Others , AMPK
T0368	Cinepazide maleate	MD-67350,Vasodistal,Brendil	Calcium Channel
	Cinepazide maleate (MD-67350), a maleate salt form of cinepazide, is a vasodilator.		Calcium Channel
T3230	NLRP3-IN-2	5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I	NOD-like Receptor (NLR) , NOD
	NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...		NOD-like Receptor (NLR) , NOD
T70540	Pinokalant	LOE-908	SARS-CoV , TRP/TRPV Channel
	Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischem...		SARS-CoV , TRP/TRPV Channel
T35689	MTP 131 acetate		Others
	MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging...		Others
T11806	L-NIO dihydrochloride		NOS
	L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM...		NOS
T81037	Tat-HA-NR2B9c
	Tat-HA-NR2B9, comprising an HIV-1 Tat transduction domain fragment, an influenza virus hemagglutinin (HA) epitope-tag, and the C-terminal 9 amino acids of NR2B (NR2B9c), has demonstrated efficacy in reducing infarct size...
T75870	PR-39 TFA
	PR-39 TFA, a natural peptide rich in proline and arginine with antibacterial properties, acts as a noncompetitive, reversible, and allosteric inhibitor of the proteasome. It specifically attaches to the α7 subunit of the...
T37671	CAY10608	CAY10608
	N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that pot...
T70883	Moexipril-d5
	Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to ...
T73453	MRS4719
	MRS4719, a potent P2X4 receptor antagonist, exhibits a half-maximal inhibitory concentration (IC50) of 0.503 μM for the human P2X4 receptor. Demonstrating both neuroprotective and neuro-rehabilitative effects, it can dec...
T83730	Tat-M2NX TFA
	Tat-M2NX, a peptide antagonist of transient receptor potential melastatin 2 (TRPM2), blocks hydrogen peroxide-induced calcium influx in HEK293 cells expressing human TRPM2 at concentrations between 25 to 100 µM. In male ...
T71402	Nicorandil-d4
	Nicorandil-d4 is intended for use as an internal standard for the quantification of nicorandil by GC- or LC-MS. Nicorandil is an activator of sulfonylurea receptor 2B (SUR2B) linked to ATP-sensitive potassium channel Kir...
T21989	SSR 69071
	SSR69071 is a potent, orally active, and selective inhibitor of neutrophil elastase. SSR69071 displays a higher affinity for human elastase (Ki =0.0168 nM) than for rat (Ki =3 nM), mouse (Ki =1.8 nM), and rabbit (Ki = 58...
T83695	MOG Peptide (human, bovine) acetate	Myelin Oligodendrocyte Glycoprotein Peptide
	Myelin oligodendrocyte glycoprotein (MOG) peptide, a truncated form of MOG located on the extracellular myelin sheath surface, interacts with antigen serotype HLA-DR2 to mitigate effects of ischemic stroke induced by mid...
T83777	LAU-0901
	LAU-0901, a platelet-activating factor (PAF) receptor antagonist, demonstrates efficacy in reducing infarct volume and enhancing neurological function in rats subjected to middle cerebral artery occlusion (MCAO)-induced ...
T35463	(±)14(15)-EET	(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i...
T83727	Tat-NTS Peptide TFA	Tat-Nuclear Translocation Signal Peptide
	Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran...
T83729	Tat-CIRP TFA	Tat-Cold-inducible RNA Binding Protein
	Tat-CIRP, a peptide inhibitor, impedes the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP) by binding to MD-...
T83769	TC 14012 hydrochloride	H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2
	TC 14012, a peptidomimetic compound, acts as both an antagonist to the chemokine (C-X-C motif) receptor 4 (CXCR4; IC50 = 2.9 nM) and as an agonist for CXCR7, effectively recruiting β-arrestin in HEK293T cells that expres...
T83682	Tat-Gap 19 TFA
	Tat-Gap 19, a peptide inhibitor of connexin43 (Cx43) hemichannels, is derived from the HIV-1 Tat protein transduction domain fused with a nine-amino acid sequence from Cx43 residues 128-136. This compound, at a concentra...
T83731	Tat-CBD3 TFA
	Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ...
T83825	Trofinetide acetate	NNZ-2566
	Trofinetide, derived from the neuroprotective tripeptide Gly-Pro-Glu (an N-terminal sequence of insulin-like growth factor-1, IGF-1), shows promise in various neuroprotective models. At a concentration of 10 nM, it mitig...

Compounds

Dapansutrile

T15052

Synonym:

Target: NOD-like Receptor (NLR), NOD

SCH79797 dihydrochloride

T12870

Synonym:

Target: Apoptosis, Others, Protease-activated Receptor

Annaosanchun

T19659

Synonym: YC6,YC-6,YC 6

Target: Others, AMPK

Cinepazide maleate

T0368

Synonym: MD-67350,Vasodistal,Brendil

Target: Calcium Channel

NLRP3-IN-2

T3230

Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I

Target: NOD-like Receptor (NLR), NOD

Pinokalant

T70540

Synonym: LOE-908

Target: SARS-CoV, TRP/TRPV Channel

L-NIO dihydrochloride

MOG Peptide (human, bovine) acetate

T83695

Synonym: Myelin Oligodendrocyte Glycoprotein Peptide

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target:

Tat-NTS Peptide TFA

T83727

Synonym: Tat-Nuclear Translocation Signal Peptide

Target:

Tat-CIRP TFA

T83729

Synonym: Tat-Cold-inducible RNA Binding Protein

Target:

TC 14012 hydrochloride

T83769

Synonym: H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-D-Cit-Pro-Tyr-Arg-Cit-Cys-Arg-NH2

Cat No.	Product Name	Synonyms	Targets
T6S1294	Nicotiflorin	Nictoflorin,Kaempferol-3-O-Rutinoside,Nicotifloroside	Others
	1. Nicotiflorin (Kaempferol-3-O-Rutinoside) has potential therapeutic effects on cerebral ischemic illness. 2. Nicotiflorin has protective effects on reducing memory dysfunction, energy metabolism failure and oxidative s...		Others
T0905	Pyrithioxin	Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen	Others , Endogenous Metabolite
	Pyrithioxin (Encefabol) is a neurodynamic compound, combined with a short period of hyperventilation (HV) was applied in cerebral infarct patients with Hemiplegia. Pyrithioxin is regarded as an encephalotropic or nootrop...		Others , Endogenous Metabolite
T2973	Astragaloside IV	AST-IV,AS-IV	MMP , ERK , Estrogen/progestogen Receptor , JNK
	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...		MMP , ERK , Estrogen/progestogen Receptor , JNK

Natural Products

Nicotiflorin

T6S1294

Synonym: Nictoflorin,Kaempferol-3-O-Rutinoside,Nicotifloroside

Target: Others

Pyrithioxin

T0905

Synonym: Pyridoxine disulfide,Encefabol,Vitamin B6 disulfide,Pyritinol,Bonifen

Target: Others, Endogenous Metabolite

Astragaloside IV

T2973

Synonym: AST-IV,AS-IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00803	Fibronectin Protein, Human, Recombinant (aa 607-1265, His)	Human	HEK293
	Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet ...
TMPY-05053	ANGPTL2 Protein, Human, Recombinant (His)	Human	HEK293
	The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
TMPY-03998	ANGPTL2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	The angiopoietin-like protein (ANGPTL) family is homologous to angiopoietins but does not bind to the Tie2 receptor. The function of ANGPTLs has been elucidated largely in the context of angiogenesis and lipid metabolism...
TMPY-05562	Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)	Human	HEK293
	Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet ...

Fibronectin Protein, Human, Recombinant (aa 607-1265, His)

TMPY-00803

Species: Human

Expression System: HEK293

ANGPTL2 Protein, Human, Recombinant (His)

TMPY-05053

Species: Human

Expression System: HEK293

ANGPTL2 Protein, Mouse, Recombinant (hFc)

TMPY-03998

Species: Mouse

Expression System: HEK293

Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)

TMPY-05562

Species: Human

Expression System: HEK293