isoxazole

Isoxazole (1,2-oxazole) is the inhibitor of acetylcholinesterase (AChE). The ligands of Isoxazole bind to and inhibit the Sxc- antiporter.

methyl 5-(3,4-dimethoxyphenyl)isoxazole-3-carboxylate is a biochemical.

5-Chloro-3-phenylbenzo[c]isoxazole is a useful organic compound for research related to life sciences. The catalog number is T66589 and the CAS number is 719-64-2.

ISX-9 (Isoxazole 9) is necessary to activate neuron-specific genes as neurogenesis inducer.

5-(2-furyl)-N-propylisoxazole-3-carboxamide is a compound used as a molecular structural unit and is thought to be a modulator of NMDA receptors, and has been shown to be protective against glutamate-induced excitotoxicity and oxidative stress in neuronal cells. It has also been found to have anti-inflammatory activity, making it a potential therapeutic agent for diseases such as Alzheimer's disease and Parkinson's disease.

TP748 is a key intermediate for fully synthetic tetracyclines, and is an isoxazole.

PNZ5, an isoxazole-based pan-BET inhibitor, demonstrates potent activity and high selectivity comparable to the established (+)-JQ1, exhibiting a dissociation constant (KD) of 5.43 nM for BRD4(1).

Sulfisoxazole diethanolamine, also known as Sulfafurazole diethanolamine, is a sulfonamide antibacterial compound with an oxazole substituent. It acts as an endothelin receptor antagonist, specifically targeting endothelin receptor A with an IC50 value of 0.60 μM and endothelin receptor B with an IC50 value of 22 μM. Additionally, Sulfisoxazole diethanolamine has been found to inhibit the release of breast cancer exosomes by specifically targeting endothelin receptor A [1] [2].

3-Amino-5-methylisoxazole is pharmaceutical intermediates, used in the production of sulfonamide drugs.

Pyrisoxazole is a novel fungicide inhibitor of Sterol 14α-demethylase.

5-Methyl-3-phenylisoxazole-4-carbonyl chloride is a useful organic compound for research related to life sciences. The catalog number is T64868 and the CAS number is 16883-16-2.

Sulfisoxazole (Sulfafurazole) is a short-acting sulfonamide antibacterial with activity against a wide range of gram-negative and gram-positive organisms.Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.

5-Methyl-3-(2'-chlorophenyl)-4-isoxazolecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65275 and the CAS number is 23598-72-3.

5-Methyl-3,4-diphenylisoxazole is a useful organic compound for research related to life sciences. The catalog number is T66198 and the CAS number is 37928-17-9.

Sulfisoxazole acetyl (Gantrisin) is an agent with antibacterial activity. Sulfisoxazole acetyl is a Sulfisoxazole derivative with antibacterial activity. Sulfisoxazole acetyl is an inhibitor of dihydropteroate synthase.

5-Methylisoxazole-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66496 and the CAS number is 42831-50-5.

3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T65267 and the CAS number is 3919-74-2.

Clomazone (Magister) is an agricultural herbicide. The molecule consists of a 2-chlorobenzyl group bound to an N-O heterocycle called Isoxazole. Clomazone suppresses the biosynthesis of chlorophyll and other plant pigments.

VGX-1027 (GIT 27) is an isoxazole compound with various immunomodulatory properties.

MK-8245 trifluoroacetate is a phenoxy piperidine isoxazole derivative functioning as a potent, liver-targeting stearoyl-CoA desaturase (SCD) inhibitor, demonstrating significant anti-diabetic and anti-dyslipidemic effects. It showcases high specificity and efficacy against SCD1 across various species, with IC50 values of 1 nM for human SCD1 and 3 nM for both rat and mouse SCD1. MK-8245's mechanism includes a tetrazole acetic acid moiety that facilitates liver-targeting through OATPs recognition. Its inhibition potency in rat hepatocyte assays (IC50 of 68 nM) surpasses that in HepG2 cell assays devoid of active OATPs (IC50 of ~1 μM), highlighting its liver specificity. Moreover, MK-8245 exhibits over 100,000-fold selectivity against Δ-5 and Δ-6 desaturases in comparative assays. In vivo studies reveal MK-8245's preferential liver distribution in mice, rats, dogs, and rhesus monkeys, underscoring its potential for minimizing adverse effects in non-target tissues. Additionally, its administration in eDIO mice before glucose challenges significantly improves glucose clearance, indicating its therapeutic promise in diabetes management.

Muscimol hydrochloride (Agarin; Agarine) is an isoxazole compound known for its psychoactive properties, acting as a potent selective agonist of GABA A receptors (EC 50 =0.2 μM), a partial agonist of GABA C receptors, and exhibiting inactivity at GABA B receptors. This substance is derived from Amanita muscaria and related mushroom species. It exerts calming, anti-anxiety, and hallucinatory effects [1].

Mtb-IN-4 (compound 17h) is a non-toxic isoxazole that exhibits anti-Mycobacterium tuberculosis (Mtb) activity, with an IC50 value of 0.70 μM. It impedes Mtb respiration and biofilm formation within macrophages and augments the efficacy of the antibiotic isoniazid (INH) against INH-resistant Mtb mutants [1].

Mtb-IN-5 (compound (-)17j) is an isoxazole exhibiting anti-Mycobacterium tuberculosis (Mtb) activity. It impedes Mtb respiration and biofilm formation within macrophages and augments the efficacy of the antibiotic isoniazid (INH) against INH-resistant Mtb mutants [1].

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells. FM26 is a potent and allosteric retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonists with an IC50 of 264 nM.

MRL-871 (compound 3) is a potent isotretinoin receptor-related orphan receptor γt (RORγt) inverse agonist (IC50: 264 nM).MRL-871 has a specific isoxazole chemotype and is effective in reducing IL-17a mRNA production in EL4 cells.

Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.