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l 778123

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  • Inhibitors & Agonists
    4
    TargetMol | Activity
L-778123 hydrochloride
L 778123
T3182253863-00-2
The L-778123 hydrochloride is an inhibitor of FPTase (IC50: 2 nM) and GGPTase-I (IC50: 98 nM) in enzyme inhibition determination.
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TargetMol | Citations Cited
L-778123 Dihydrochloride
T70134183499-56-1
L-778123 is an inhibitor of FPTase and GGPTase-I, which was developed in part because it can completely inhibit Ki-Ras prenylation. The combination of L-778,123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer. Radiosensitization of a patient-derived pancreatic cancer cell line was observed.
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1-2 weeks
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L-778123 free base
L-778,123,L 778123,L-778123,L778123,L 778,123
T3182L183499-57-2
L-778123 is an inhibitor of FPTase and GGPTase-I. The combination of L-778123 and radiotherapy at dose level 1 showed acceptable toxicity in patients with locally advanced pancreatic cancer.
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1-2 weeks
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BAY-846
T701331836185-18-2
BAY-846 is an allosteric MEK inhibitor with long half-lives, high bioavailabilities, low brain penetration potential and high efficacy in a K-Ras-mutated A549 xenograft model.
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6-8 weeks
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