lanoconazole

Lanoconazole is an orally active imidazole antifungal agent that displays a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis.

(Z)-Lanoconazole is the Z configuration of Lanoconazole, used for investigating dermatophytosis and onychomycosis. It inhibits sterol 14-alpha demethylase, disrupting fungal membrane ergosterol biosynthesis. Lanoconazole is a potent, orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2].

(Z)-Tyrphostin A51, the Z configuration of Lanoconazole A51, is a potent protein tyrosine kinase (PTK) inhibitor that dose-dependently inhibits the volume-sensitive release of [3 H]taurine in primary astrocyte cultures. It significantly reduces cellular tyrosyl phosphorylation levels and inhibits both basal and EGF-induced human bone cell proliferation [1] [2].