locally acting

4-Nonylphenol polyethoxylate (Nonoxinol-9) is a typical surfactant used as a vaginal spermicide. Spermicides are locally acting non-hormonal contraceptives. When present in the vagina during intercourse, they immobilize/inactivate/damage and/or kill sperms without eliciting systemic effects. 4-Nonylphenol polyethoxylate has been in use for more than 30 years as an over-the-counter (OTC) drug in creams, gels, foams and condom lubricants. It is the most commonly used spermicidal contraceptive in the UK and the USA. In several European countries, spermicides are no longer on the market.

Sulbentine (Dibenzthione) is an antifungal agent.

Sovesudil (PHP-201) is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor. Sovesudil shows IC50 s of 3.7 and 2.3 nM for ROCK-I and ROCK-II, respectively. Sovesudil can lower intraocular pressure (IOP) without inducing hyperemia.

Sovesudil (PHP-201) hydrochloride is a potent, ATP-competitive, locally acting Rho kinase (ROCK) inhibitor that acts on ROCK I (IC50: 3.7 nM) and ROCK II (IC50: 2.3 nM). Sovesudil hydrochloride is capable of lowering IOP without causing congestion.

Benzydamine hydrochloride (AF864), a locally-acting nonsteroidal anti-inflammatory drug, has local anaesthetic and analgesic properties.