mal nh peg4 ch2ch2coopfp ester

Mal-NH-PEG4-CH2CH2COOPFP ester, a polyethylene glycol (PEG) based linker, is used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

1,2-Bis(2-iodoethoxy)ethane is a PEG-based PROTAC linker used in the synthesis of MT802 and SJF620, which are potent PROTAC BTK degraders with DC50s of 1 nM and 7.9 nM, respectively [1].

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

N3-PEG4-C2-NHS ester is a noncleavable, four-unit polyethylene glycol (PEG) linker essential for the synthesis of antibody-drug conjugates (ADCs).

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

dMCL1-2 is a potent and selective myeloid leukemia 1 (MCL1) degrading agent based on PROTAC, binding to MCL1 with a KD of 30 nM and activating the apoptosis mechanism by degrading MCL1.

Boc-NH-PEG3-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs.

PROTAC ERRα ligand 2 is an inverse agonist for the estrogen-related receptor α (ERRα) with an IC50 of 5.67 nM.

Fmoc-NH-PEG8-NHS ester is a PEG-based PROTAC linker employed in PROTAC synthesis [1].

TSPO ligand-2 (Carbonic acid) is a ligand of AUTAC1 which contains a p-fluorobenzylguanine and a Fumagillol moiety.

Boc-NH-PEG4-CH2CH2NH2 is a cleavable 5-unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Boc-NH-O-C1-NHS ester, an alkyl ether-based PROTAC linker, is utilized in PROTAC synthesis.

Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker suitable for use in PROTAC synthesis [1].

Hydroxy-PEG4-(CH2)2-Boc is an uncleavable ADC linker utilized in the synthesis of antibody-drug conjugates (ADCs) and can also be employed in the synthesis of PROTAC.

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

N-Boc-cis-4-hydroxy-L-proline methyl ester serves as a non-cleavable linker in antibody-drug conjugate (ADC) synthesis and functions as an alkyl chain-based PROTAC linker for PROTAC construction [2].

Mal-PEG1-NHS ester is a cleavable, PEG-based linker utilized in the synthesis of antibody-drug conjugates (ADCs) and PROTACs, serving as both an ADC linker and a PROTAC linker. [Mal-PEG1-NHS ester]

DNP-NH-PEG4-C2-Boc is a PEG-based linker used in PROTACs, which joins two essential ligands crucial for forming PROTAC molecules and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Fmoc-PEG4-NHS ester is a PEG-based linker for PROTACs, essential for joining two key ligands to form PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Bis-Mal-Lysine-PEG4-TFP ester, a PEG-based PROTAC linker, facilitates PROTAC synthesis[1].

Boc-NH-PEG-amine (MW 2000) is a polyethylene glycol (PEG) linker utilized in PROTAC synthesis[1].

PROTAC BET-binding moiety 2 is an inhibitor of the BET bromodomain.

.trans-4-Hydroxy-D-proline methyl ester hydrochloride (catalog number: T65562, CAS number: 481704-21-6) is a valuable organic compound for life sciences research.

PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].

NH-bis(PEG4-acid) is a PEG-based linker used in PROTACs to connect two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

N-Boc-PEG-t-butyl ester is a PEG-based linker for PROTACs, joining two essential ligands to facilitate selective protein degradation via the ubiquitin-proteasome system within cells.

SNIPER(TACC3)-2 targets TACC3 protein degradation via the ubiquitin-proteasome pathway. It induces cancer cell death.

Thalidomide-O-amido-PEG1-(C1-PEG)2-C2-NH2 is a synthesized E3 ligase ligand-linker, incorporating a cereblon ligand based on Thalidomide and a 3-unit PEG linker, specifically designed for PROTAC technology applications.

4-N3Pfp-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Thalidomide-O-PEG4-NHS ester is a polyethylene glycol (PEG)-based linker commonly used in the synthesis of proteolysis-targeting chimeras (PROTACs)[1].

Mal-NH-ethyl-SS-propionic acid, a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1], plays a crucial role in the modulation of drug release from the conjugate.

N-(Azido-PEG4)-N-bis(PEG4-NHS ester), a PEG-based PROTAC linker, is an essential component in PROTAC synthesis [1].

6-O-2-Propyn-1-yl-D-galactose functions as an irreversible glycolinker, facilitating the attachment of cytotoxic drugs for applications in antibody-drug conjugation (ADC).

NH2-PEG4-Glu(OH)-NH-m-PEG24 is a PEG-based PROTAC linker suitable for PROTAC synthesis [1].

Mal-NH-PEG14-CH2CH2COOPFP ester is a polyethylene glycol-based (PEG) linker used in PROteolysis TArgeting Chimeras (PROTACs) [1].

Mal-amido-PEG9-NHS ester is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, and enabling selective protein degradation by leveraging the ubiquitin-proteasome system [within cells].

rm-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker utilized for the synthesis of PROTACs[1].

Bis-PEG4-t-butyl ester, a PEG-based linker for PROTACs, facilitates the formation of PROTAC molecules by connecting two essential ligands, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-amido-PEG2-TFP ester is a polyethylene glycol (PEG)-based linker featuring amide functionality and a trifluorophenyl (TFP) ester group, used in PROTAC synthesis as a PEG-based PROTAC linker [1].

Bis (2-bromoethyl) ether, an alkyl chain-derived PROTAC linker, facilitates the synthesis of PROTACs.

Mal-PEG4-NHS ester is a noncleavable ADC linker with a Maleimide group, a 4-unit PEG, and an NHS ester.

NH-bis(PEG4-Boc) is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the selective protein degradation via the ubiquitin-proteasome system within cells.

Endo-BCN-PEG4-PFP ester is a polyethylene glycol (PEG) derivative, specifically designed as a linker for proteolysis-targeting chimeras (PROTACs) [1].

PC DBCO-PEG4-NHS ester, a PEG-based linker for PROTACs, connects two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Mal-PEG4-VC-PAB-DMEA, a cleavable ADC linker incorporating a Maleimide moiety, is employed in the synthesis of antibody-drug conjugates (ADCs)[1].

Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

N-Desthiobiotin-N-bis(PEG4-NHS ester) is a polyethylene glycol (PEG) derived linker utilized in the synthesis of PROTACs [1].

Bromo-PEG4-NHS ester is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

DBCO-(PEG2-Val-Cit-PAB)2 is a dual-cleavable linker used in antibody-drug conjugates (ADCs).