ML116 is a potent and selective STAT3 inhibitor.

Diaporthein B, a highly oxidized pimarane diterpene, demonstrates significant activity against M. tuberculosis with a MIC of 3.1 μg/mL and exhibits IC50 values ranging from 1.5-3 μM/L against HCT 116 and LoVo colon cancer cells [1].

Rostratin C, a cytotoxic disulfide, exhibits in vitro cytotoxicity against human colon carcinoma (HCT-116), demonstrating an IC50 value of 0.76 μg/mL.

Curcuphenol in concentrations in the range of 29-116 µg/ml inhibited cell proliferation and DNA replication and induced cell death in a dose-dependent manner.

Verrucarin J (Muconomycin B), derived from the Myrothecium fungus family, effectively generates reactive oxygen species (ROS) to induce apoptosis in various cancer cell lines, including A549, HCT 116, and SW-620. Besides its anticancer properties, it exhibits antifungal activity against Candida albicans and Mucor miehei. Furthermore, it notably inhibits the arenavirus Junin (JUNV) yield with an IC 50 of 1.2 ng/mL.

Rostratin A, a cytotoxic disulfide isolated from the marine-derived fungus Exserohilum rostratum, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an inhibitory concentration 50 (IC 50) value of 8.5 μg/mL.

Rostratin B, a cytotoxic disulfide, demonstrates in vitro cytotoxicity against human colon carcinoma (HCT-116), exhibiting an IC50 value of 1.9 μg/mL.