nachr1

α7 nAchR-JAK2-STAT3 agonist 1 is a potent inhibitor of the α7 nAchR-JAK2-STAT3 pathway that acts on nitric oxide (NO) (IC50: 0.32 μM). α7 nAchR-JAK2-STAT3 agonist 1 has been shown to have a positive effect on iNOS, IL-1β and IL-1β in murine macrophages RAW264.7. α7 nAchR-JAK2-STAT3 agonist 1 was effective in inhibiting the expression of iNOS, IL-1β and IL-6 in mouse macrophages. α7 nAchR-JAK2-STAT3 agonist 1 inhibited LPS-induced NO release, NF-κB activation and cytokine production. α7 nAchR-JAK2-STAT3 agonist 1 was able to be used to study sepsis.

nAChR antagonist 1 (compound B15) is a highly effective antagonist of α7 nAChR, demonstrating an IC50 value of 3.3 μM. Its versatility makes it an ideal candidate for investigating the pathogenesis of schizophrenia, Alzheimer's disease, and inflammatory disorders [1].

nAChR modulator-1, a insecticide, is a insect nAChR orthosteric modulator [1] .

nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator.

Sulfoxaflor (GF 2032), an agonist of nAChR1 and nAChR2 subtypes, is a systemic insecticide that acts on the central nervous system of insects. Sulfoxaflor is used for the control of sap-feeding insects such as Nilaparvata lugens, Bemissia tabaci, Myzus persicae, an