OICR-9429 is a potent antagonist of the interaction that WDR5 effect with peptide regions of MLL and Histone 3. It reduces the viability of acute myeloid leukemia cells in vitro.

OICR-9429-N-C2-NH2, a ligand for WDR5, intermediate 2, serves as a crucial compound in the synthesis of PROTACs.

Dimethyl-F-OICR-9429-COOH, a ligand for WD40 repeat domain protein 5 (WDR5). This compound is utilized as a key component in the synthesis of PROTACs.

WDR5-IN-6 is a WDR5 inhibitor targeting the WBM locus.WDR5-IN-6 is highly synergistic with OICR-9429, a WDR5 inhibitor that targets the WIN locus.WDR5-IN-6 exhibits potent antitumor activity and inhibits cell proliferation in neuroblastoma cell lines.WDR5-IN-6 can be used in neuroblastoma research. WDR5-IN-6 can be used in neuroblastoma research.

OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule Wdr5-MLL interaction antagonist.