patamostat

Patamostat (E-3123) is a potent protease inhibitor that effectively inhibits trypsin, plasmin, and thrombin, exhibiting IC50 values of 39 nM, 950 nM, and 1.9 µM, respectively. Research suggests that Patamostat might suppress the pathogenesis and development of acute pancreatitis [1] [2].

Patamostat HCl is a highly potent and selective small molecule protease (protease) inhibitor that inhibits trypsin, fibrinolytic enzymes, and thrombin with IC50 values of 39 nM, 950 nM, and 1.9 μM, respectively.Patamostat HCl is used in the study of acute pancreatitis.

Patamostat (E-3123) mesylate is a histone deacetylase (HDAC) inhibitor.Patamostat mesylate increases the accumulation of acetylated histones and microtubule proteins in tumor cells, contributing to cell cycle termination and apoptosis.Patamostat mesylate has antitumor activity and can be used in the study of multiple myeloma.