Polygalacic acid (Virgaureagenin G)(PA) significantly improves cholinergic system reactivity, as indicated by decreased acetylcholinesterase (AChE) activity, increases choline acetyltransferase (ChAT) activity, and elevates levels of acetylcholine (ACh) in the hippocampus and frontal cortex, PA also significantly ameliorates neuroinflammation and oxidative stress in mice; suggest that PA might exert a significant neuroprotective effect on cognitive impairment, driven in part by the modulation of cholinergic activity and neuroinflammation. Polygalacic acid shows significant postingestive effects on Spodoptera littoralis larvae.

Polygalacin D shows anti- proliferation, anti-inflammary, and hepatoprotective activities, it can inhibit the expression of lipopolysaccharide (LPS)-induced iNOS and COX-2 protein and mRNA without an appreciable cytotoxic effect on RAW 264.7 macrophages, and can suppress induction by LPS of pro-inflammatory cytokines such as prostaglandin E2 (PGE2).

Rhamnetin 3-O-β-D-glucopyranoside, a flavonoid derivative, is isolated from the roots of Polygala sibirica L. (Polygalaceae) [1].

Bayogenin 3-O-beta-D-glucopyranoside is a natural product from Polygala japonica Houtt.

6-Hydroxy-1,2,3,7-tetramethoxyxanthone is a natural product from Polygala sibirica L.

Onjisaponin Z is a natural product

1,7-Dihydroxy-2,3-methylenedioxyxanthone has antiulcerogenic, anti-oxidation, and antihyperalgesic activities, it can inhibit the carrageenan-induced hyperalgesia.

Polygalasaponin XLIX is a natural product for research related to life sciences. The catalog number is TN6532 and the CAS number is 1033593-12-2.

Polygalasaponin XXXV is a natural product for research related to life sciences. The catalog number is TN6533 and the CAS number is 184479-28-5.

Arillanin A is a natural product from Polygala tenuifolia Willd.

Sibiricaxanthone A (Sibiricaxanthone A) is a natural product from Polygala tenuifolia

1,3,7-Trihydroxy-2-methoxyxanthone shows different anti-oxidation activities.

1. Sibiricose A6 displays antidepressant-like action, it may prevent or relieve depression. 2. Sibiricose A6 shows potent antioxidant activity.

Tenuifoliose J is a natural product from Polygala tenuifolia Willd

Polygalin C is a natural product for research related to life sciences. The catalog number is TN6529 and the CAS number is 934768-05-5.

Tenuifoliose A is a natural product from Polygala tenuifolia Willd.

1,7-Dimethoxy-2,3-methylenedioxyxanthone is a natural product for research related to life sciences. The catalog number is TN2521 and the CAS number is 145523-71-3.

Polygalasaponin E is a natural product for research related to life sciences. The catalog number is TN6531 and the CAS number is 882664-72-4.

Polygalaxanthone III can significantly inhibit chlorzoxazone 6-hydroxylation catalyzed by CYP2E1.

1,7-Dihydroxy-2,3-dimethoxyxanthone may have medicinal use in the management of inflammation, asthma and allergy, it antagonises in a non competitive but, reversible manner the contractions induced by chemical inflammatory mediators in the guinea pig trac

Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-synuclein, it may have potential therapeutic effects on Parkinson disease, Alzheimer disease and Huntington disease.

4-Hydroxyvertixanthone is a natural product for research related to life sciences. The catalog number is TN4522 and the CAS number is 85003-85-6.

Securoside A is a natural product for research related to life sciences. The catalog number is TN6517 and the CAS number is 107172-40-7.

Sibiricaxanthone B is an xanthone isolated from C. breviscapa and has sedative, anticonvulsant and antidepressant properties.

Tenuifoliside B is a natural product from the roots of Polygala tenuifolia.And is a target lactate dehydrogenase inhibitor. Tenuifoliside B has cognitive improving and cerebral protective effects. it can inhibit potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice.

7-O-MethylMangiferin is an xanthone isolated from the rhizomes of Iris nigricans.

Tenuifoliside A has anti-apoptotic , neuroprotective activity. And tenuifoliside A has anti-inflammatory effect, which is mediated by the inhibition of the NF-κB and MAPK pathways.

3',6-Disinapoylsucrose (Disinapoyl sucrose) shows the neuroprotective effect and antidepressive activity in rats.

7-Z-Trifostigmanoside I is a natural product from Polygala hongkongensis Hemsl.

Tenuifolin has no inherent toxicity to either the transfected or wild type cells at the effective concentrations, it inhibits amyloid-β secretion in vitro.

Polygalic acid (Senegenic acid), a triterpenoid saponin, is a major active ingredient in Polygala tenuifolia. Polygalic acid shows expectorant, emetic and stimulant effects.

Tenuifoliside C, isolated from polygala tenuifolia willd, is a target lactate dehydrogenase inhibitor. It significantly inhibits chlorzoxazone 6-hydroxylation catalyzed by CYP2E1[1].

Sibiricose A5 is a lactate dehydrogenase inhibitor, it displays antidepressant-like, and antioxidant actions. Sibiricose A5 can protect PC12 cells damage induced by P. tenuifolia.

Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Polygalasaponin F can significantly i

Glomeratose A is a lactate dehydrogenase inhibitor.

Sibiricose A1 is a natural product for research related to life sciences. The catalog number is TN5016 and the CAS number is 139726-40-2.

Polygalasaponin possesses evident anxiolytic and sedative-hypnotic activities and has a relatively safe dose range, which supports the use of Polygala tenuifolia root as an anxiolytic and sedative-hypnotic drug in folk medicine.

Methyl 8-hydroxy-3-(2-methoxy-2-oxoethyl)-6-methyl-9-oxo-9H-furo[3,4-b]chromene-1-carboxylate is a natural product for research related to life sciences. The catalog number is TN4537 and the CAS number is 96287-41-1.

Onjixanthone II is a natural product from Polygala tenuifolia.

Polygalin J can be used in research related to life sciences and its product number is TN6530.

1,2,3,7-Tetramethoxyxanthone is a natural product from Polygala tenuifolia Willd.

Tenuigenin (Senegenin) is a natural product from Polygala tenuifolia used in Chinese medicine with antioxidative and anti-inflammatory activity.

Lancerin, extracted from the root bark of Cudrania cochinchinensis, exhibits antioxidative activity against lipid peroxidation.

Polygalaxanthone XI is an xanthone glycoside isolated from the cortex of Polygala tenuifolia, which can be used in studies of expectorants and to promote psychostability.

(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) is a natural product from the roots and rhizomes of Notopterygium incisum.

1,2,3,6,7-Pentamethoxyxanthone is a natural product from Polygala tenuifolia.

Polygalacin D2 may have antimicrobial activity.

Arganine B is a natural product for research related to life sciences. The catalog number is TN6438 and the CAS number is 144425-21-8.

Sibiricose A4 is a natural product for research related to life sciences. The catalog number is TN6439 and the CAS number is 241125-73-5.