quinpirole

Quinpirole is a dopamine D2/D3 receptor agonist.

Quinpirole Hydrochloride (LY 171555), as an agonist with high affinity for dopamine receptor D2 D3, has been widely used to study the function of dopamine receptor D2 D3 in humans and mice

Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.

NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).

Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.

Eticlopride is a potent and selective D2 receptor antagonist that has been studied in rats with extensive dopamine denervation induced by 6-hydroxydopamine. Administering Eticlopride daily for 21 days increases D2 receptor density in intact brain regions; however, it does not further elevate the already increased density in denervated areas. Despite changes in receptor density, functional sensitivity remains evident, as demonstrated by the contralateral rotations induced by the D2 agonist quinpirole during the washout period. This study suggests that chronic D2 receptor blockade and dopamine denervation may share a common mechanism in upregulating D2 receptor density, contrary to previous reports of additive effects with denervation and antagonist treatment.

SKF-80723 HBr is a D1 receptor agonist. SKF-80723 HBr strongly potentiated the contralateral circling induced by quinpirole in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the medial forebrain bundle.

PD 89211 is a selective dopamine D4 receptor antagonist with high selectivity for the DA D4.2 receptor (> 800-fold) as compared to other hDA receptor subtypes, rat brain serotonin, and adrenergic receptors. In vitro, PD 89211 reverses quinpirole-induced [