quipazine

Quipazine, a 5-HT (serotonin) agonist, demonstrates affinity for the 5-HT3R receptor in rats with a Ki value of 1.4 nM, effectively displacing GR65630. It exhibits antiviral activity against SARS-CoV-2, achieving an EC50 of 31.64 μM. Additionally, Quipazine acts as a 5-HT3R agonist in peripheral models, indicating its potential for neurological disease research.

Quipazine dimaleate is a selective 5-HT3 agonist.

Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors. Like quipazine, quipazine derivatives produce contracture of smooth muscle organs and bronchospasm.

Seganserin, a non-selective 5-hydroxytryptamine 2-HT receptor antagonist, reversed the inhibitory effects of fluoxetine and quipazine on luteinizing hormone-induced hyperphagia, depression and nociception, and reversed the antidepressant and analgesic effects induced by fluoxetine and quipazine.

N-Methylquipazine is an agonist of 5-HT3. It has almost the same affinity for 5-HT3 sites as quipazine.

5-HT3 agonist