sarm

SARM1-IN-2 is a potent SARM1 inhibitor for the study of metabolic and neurological related diseases.

Sarmazenil (Ro 15-3505) is a partial inverse agonist at the benzodiazepine receptor with pro-convulsant properties and is used in the study of chronic hepatic encephalopathy (HE).

Sarmustine (SarCNU) is an alkylating agent with anticancer activity that inhibits the growth of prostate cancer cells via p53-dependent and p53-independent pathways.Sarmustine mediates the selection of P140K methylguanine-DNA-methyltransferase-transduced human CD34(+) cells in vitro.

S-23 ((S)-3-(4-chloro-3-fluorophenoxy)-N-(4-cyano-3-(trifluoromethyl)phenyl)-2-hydroxy-2-methylpropanamide) is an oral selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats.

RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.

Ostarine (MK-2866) is a non-steroidal agent with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone's action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.

Sarmenoside III, a hepatoprotective flavonol glycoside, has been isolated from the plant Sedum sarmentosum.

Sarmenoside II, a flavonol glycoside, demonstrates inhibitory activity on lipid accumulation. It has been observed to reduce albumin-oleate-induced lipid accumulation in HepG2 cells by approximately 30% at a concentration of 100 μM.

Sarmentocymarin is a cardiac glucoside.

SarMentine is a natural product for research related to life sciences. The catalog number is TN6781 and the CAS number is 78910-33-5.

Sarmentosin significantly lowers the SGPT level of patients suffering from chronic viral hepatitis, and shows a suppressive effect on cell-mediated immune responses in mice. It shows a good effect in lowering serum glutamate-pyruvate transaminase.

Periplogenin 3-[O-beta-glucopyranosyl-(1->4)-beta-sarmentopyranoside] is a natural product from Periploca sepiumBge.

AC-262536 is a selective androgen receptor (SAR) modulator. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone.

ACP-105 is a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone.

Ligandrol is a novel nonsteroidal, oral SARM that binds to the androgen receptor with high affinity (Ki: 1 nM) and selectivity.

Andarine (GTx-007) (S-4) is an active partial agonist and an investigational selective androgen receptor modulator (SARM).

LG-121071 is a selective androgen receptor modulator (SARM) with orally active. LG-121071 acts as a high-affinity full agonist of the androgen receptor (AR) (Ki = 17 nM).

NEP-28 is an AR agonist. NEP28 is a new SARM exhibiting high selectivity for androgen receptor. NEP28 showed tissue-selective effect equivalent to or higher than existing SARMs. In addition, the administration of NEP28 increased the activity of neprilysin, a known Aβ-degrading enzyme.

S-40503 is an investigational selective androgen receptor modulator (SARM).

PF-06260414 is a selective androgen receptor modulator or SARM used to treat muscle weakness.

JNJ-37654032 is a nonsteroidal AR ligand with mixed agonist and antagonist activity. It is an orally active SARM with muscle selectivity. It stimulated growth of the levator ani muscle with ED(50) 0.8 mg/kg, stimulating maximal growth at a dose of 3mg/kg.

GSK-2881078 is a selective androgen receptor modulator (SARM) that is being evaluated for effects on muscle growth and strength in subjects with muscle wasting to improve their physical function.