spdp-peg-12-acid

SPDP-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is used for the synthesis of antibody-drug conjugates (ADCs)[1].

SPDP-PEG5-acid is a PEG-based linker for PROTACs, connecting two essential ligands and facilitating selective protein degradation through the ubiquitin-proteasome system within cells.

SPDP-PEG7-acid is a PEG-based linker for PROTACs [Proteolysis-Targeting Chimeras] that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Fmoc-12-aminododecanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

SPDP-PEG24-acid is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation, which enables selective protein degradation via the ubiquitin-proteasome system within cells.

SPDP-PEG9-acid, a PEG-based linker for PROTACs, joins two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

SPDP-PEG4-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

m-PEG8-(CH2)12-phosphonic acid ethyl ester is a polyethylene glycol (PEG)-based PROTAC linker, ideal for synthesizing PROTAC compounds[1].