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(3)
By Target- Apoptosis
- Autophagy(2)
- LPL Receptor(2)
- S1P Receptor(5)
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Results for "
sphingosine-competitive
" in TargetMol Product Catalog- Inhibitor Products7
K145 hydrochloride
Cited
TQ01381449240-68-9In house
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
- $50
Size
QTY
CitedPF-543 hydrochloride Cited
T88401706522-79-3
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
- $33
Size
QTY
CitedPF-543 Cited
T60851415562-82-1
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
- $50
Size
QTY
Cited(R)-FTY720-OMe
T708161382486-90-9
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
- $1,520
Size
QTY
SK1- I hydrochloride
T607982366222-05-9
SK1-I hydrochloride (BML-258 hydrochloride) is a sphingosine analog that can enhance autophagy and has antitumor activity. SK1-I hydrochloride is an isozyme-specific competitive SPHK1 inhibitor (Ki = 10 μM) [1] [2].
- $332
Size
QTY
PF-543 Citrate
T124361415562-83-2
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
- $44
Size
QTY
MP-A08
T16128219832-49-2
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).
- $39
Size
QTY
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