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Search Results for " sphingosine-competitive "

Targets

7

Compounds

Cat No. Product Name Synonyms Targets
T6085 PF-543 Sphingosine Kinase 1 Inhibitor II,PF 543 Apoptosis , S1P Receptor , Autophagy , LPL Receptor
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
TQ0138 K145 hydrochloride Apoptosis , S1P Receptor
K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.
T8840 PF-543 hydrochloride PF-543 Apoptosis , S1P Receptor , Autophagy , LPL Receptor
PF-543 hydrochloride (PF-543) inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
T16128 MP-A08 S1P Receptor
MP-A08 is a highly selective ATP competitive inhibitor of sphingosine kinase (SPHK1) that targets both SphK1 and SphK2 (Ki: 6.9 ± 0.8 μM and 27 ± 3 μM, respectively).
T12436 PF-543 Citrate Sphingosine Kinase 1 Inhibitor II Citrate S1P Receptor
PF-543 Citrate is an inhibitor of sphingosine-competitive SPHK1(IC50 of 2 nM ).
T70816 (R)-FTY720-OMe
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.
T60798 SK1- I hydrochloride
SK1-I hydrochloride (BML-258 hydrochloride) is a sphingosine analog that can enhance autophagy and has antitumor activity. SK1-I hydrochloride is an isozyme-specific competitive SPHK1 inhibitor (Ki = 10 μM) [1] [2].
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