tb 5

TB5 is a potent, selective and reversible inhibitor of hMAO-B.

Glutamate-5-kinase-IN-1 (compound 50) is a potent glutamate-5-kinase (G5K) inhibitor which acts by altering the ATP binding site architecture for enzyme recognition (MIC = 4.1 μM). Glutamate-5-kinase-IN-1 has the potential for anti-TB research [1].

DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates antimycobacterial efficacy against drug-resistant strains. Additionally, it possesses high microsomal stability [1].

Glutamate-5-kinase-IN-2 (compound 54) exhibits G5K inhibition by promotes conformational changes at the L-glutamate binding site that is a potent glutamate-5-kinase (G5K) inhibitor with an MIC of 4.2 μM. Glutamate-5-kinase-IN-2 has the potential for anti-TB research [1].