tlr7 agonist 3

TLR7 agonist 3 (Compound 2), a potent activator of toll-like receptor 7 (TLR7), plays a critical role in initiating immune responses, positioning it as a promising target for immunomodulator development.

TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.

Pinocembrin 7-O-[3''-O-galloyl-4'',6''-hexahydroxydiphenoyl]-β-D-glucoside can moderately inhibit α-amylase activity, with the IC50 value of 0.03 umol/ml.

3- Phenyl- N- [1- (phenylmethyl) - 4- piperidinyl] -tricyclo[3.3.1.13, 7] decane- 1- carboxamide with antiviral activity against Ebola virus that targets the surface-exposed glycoprotein and inhibits viral entry into host cells. In vitro studies in Vero cells revealed the compound inhibits the viral replication with EC50 of 0.38 μM.

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-(1-methyl-1H-pyrazol-4-yl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl)urea, a TNF-α agonistic compound, could induce cells to secrete TNF- α.

Ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate has an inhibitory effect on coagulation factor Xa, and it can be used in the study of thrombophlebitis, atherosclerosis, cerebral embolism, stroke and pulmonary embolism.

(6Z)-7-Phenyl-7-(3-Pyridinyl)-6-Heptenoic Acid is a derivative of 7-Phenyl-7-(3-Pyridyl) -6-Heptenoic Acid that can be used in biological research.

2-(2,6-dioxopiperidin-3-yl)-4-((7-hydrox is protac.

MitoBloCK-6 is an effective inhibitor of Erv1/ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

3-[7 ,7- dimethyl-5-oxo -6H-pyrrolo[3,4-b]pyridin-2-yI]-1H-indole-7 -carbonitrile is an androgen receptor modulator.

Hemorphin-7 acetate is a hemorphin peptide, an endogenous opioid peptide derived from the β-chain of hemoglobin. Hemorphin peptides exhibits antinociceptive and antihypertensive activities, activating opioid receptors and inhibiting angiotensin-converting enzyme (ACE).

6-chloro-1-ethyl-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid is a compound used as a molecular structural unit for pefloxacin impurities.

3-(2,6-dichlorophenyl)-1-methyl-7-(methylsulfanyl)-1H,2H,3H,4H-pyrimido[4,5-d][1,3]diazin-4-one is a compound that has been extensively investigated for the treatment of a variety of disorders including tumors, Alzheimer's and Parkinson's diseases, anti-inflammatory drugs, and analgesic agents.

GPR35 agonist 3 is a synthetic GPR35 agonist with an EC50 value of 1.4 μg in the β-arrestin recruitment assay.GPR35 agonist 3 is used in the study of cancer, type 2 diabetes, and cardiovascular disease.

TLR7 agonist 2 (TLR7-IN-1) is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).

2-(4-Hydroxy-3-methoxyphenyl)-7-methoxy-5-benzofuranpropanol is a natural product for research related to life sciences. The catalog number is TN5407 and the CAS number is 144735-57-9.

3-O-Methylquercetin 4',7-di-β-D-glucopyranoside, a flavonoside, is isolated from Ophioglossum pedunculosum [1].

7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (DPHB) is a natural product for research related to life sciences. The catalog number is TN3217 and the CAS number is 79559-60-7.

Quercetin 3-O-Glc-(1→2)-Rha-7-O-Rha is a flavonol glycoside devoid of considerable inhibitory effects on lipid accumulation induced by albumin oleate.

MMP-7-IN-3 is a potent, selective MMP-7 inhibitor that effectively suppresses the progression of kidney fibrosis in a mouse model with unilateral ureteral obstruction [1].

5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (DHPA) is a pancreatic lipase inhibitor, it shows antihyperlipidemic activity.

Nurr1 agonist 7 is an agonist of Nurr1 (EC50: 0.12 μM), which can be used to study neurological disorders such as Parkinson's disease.

Luteolin-3',7-di-O-glucoside has anti-ulcer and antioxidant activities.

TLR7/8 agonist 4 hydroxy-PEG6-acid, a Drug-Linker Conjugate for ADCs, comprises the TLR7/8 agonist 4 and a hydroxy-PEG6-acid linker, suitable for the synthesis of antibody-drug conjugates (ADCs) [1].

7-Deaza-7-propargylamino-3'-azidomethyl-dATP, an analog of deoxyadenosine triphosphate (dATP), finds extensive utilization in next-generation sequencing (NGS).

7-Methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-amine is a building block.1It has been used in the synthesis of PI3K inhibitors. 1.Scott, W.J., Hentemann, M.F., Rowley, R.B., et al.Discovery and SAR of novel 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: Identification of copanlisib (BAY 80-6946)ChemMedChem.11(14)1517-1530(2016)

3'-Methoxy-3,5,4'-trihydroxyflavone-7-neohesperidoside, a flavonoid extracted from Cleome droserifolia, exhibits moderate hepatoprotective activity [1].

Compound CMC23, an FPR2 agonist, mitigates lactate dehydrogenase release in LPS-stimulated cultures and reduces pro-inflammatory IL-1β and IL-6 levels. It also attenuates phosphor-STAT3 levels through the STAT3/SOCS3 signaling pathway [1].

AHR agonist 3 is an agent with therapeutic activity.

7-Hydroxy-3-(4'-hydroxybenzylidene)-chroman-4-one may have anti-inflammatory activity.

Quercetin-3-O-sophoroside-7-O-glucoside, a naturally occurring compound, can be isolated from the leaves of Brassica rapa var. rapa [1].

7-Deaza-7-propargylamino-3'-azidomethyl-dGTP is a commonly employed deoxyguanosine triphosphate (dGTP) analog in next generation sequencing (NGS).

Kaempferol 3-O-(6''-O-acetyl)glucoside-7-O-rhamnoside is a useful organic compound for research related to life sciences and the catalog number is T124437.

Compound 7a, (Z)-(1R,3R,4R,4aS,8R,8aR)-3,4,8,8a-tetramethyl-7-oxo-4-(2-(5-oxo-2,5-dihydrofuran-3-yl)ethyl)decahydronaphthalen-1-yl 2-methylbut-2-enoate, is a clerodane diterpene [1].

5,7,3',5'-tetrahydroxy-6,4'-dimethoxyflavone exhibits anti-HIV-1 activity in the anti-syncytium assay using (∆Tat/rev)MC99 virus and 1A2 cell line system, it shows considerably activity against HIV-1 reverse transcriptase. It exhibits cytotoxic activity against P-388 cell lines, it can inhibit DNA topoisomerase IIα activity, which may be responsible for the observed cytotoxicity.

Kaempferol 3-sophoroside-7-rhamnoside is a natural product

RXFP1 receptor agonist-3 (Example 223) is an agonist of the RXFP1 receptor that inhibits cyclic AMP (cAMP) production in HEK293 cells stably expressing human RXFP1, boasting an EC50 of 2 nM [1].

3',4',7-Trimethoxyflavan is a natural product for research related to life sciences. The catalog number is T4240 and the CAS number is 116384-26-0.

(S)-7-O-Methylpeucedanol 3′-O-β-D-glucopyranoside is a coumarin glycoside [1].

Kaempferol 3-O-rutinoside 7-O-glucoside is a natural product for research related to life sciences. The catalog number is TN4370 and the CAS number is 34336-18-0.

MOR agonist-3 (Compound 84) is a dual D3R/MOR antagonist with K i values of 382 nM and 55.2 nM, respectively. It shows promise for analgesia via partial agonism at MORs and may mitigate opioid abuse via D3R antagonism. This compound is utilized in research pertaining to inflammation and neuropathic pain [1].

7-(3'-Carboxybutoxy)coumarin is a natural product for research related to life sciences. The catalog number is TN6209 and the CAS number is 16851-01-7.

Kaempferol-3-O-robinobioside-7-O-glucoside, a biflavonoid triglycoside, can be isolated from Withania somnifera [1].

The compound 6-[(1R,2S)-2,3-dihydroxy-1-methoxy-3-methylbutyl]-7-methoxy has been isolated from the stem of Angelica dahurica, marking its first discovery from a plant source [1].

Quercetin-3-O-[(6-caffeoyl)-β-glucopyranosyl (1→3) α-rhamnopyranoside]-7-O-α-rhamnopyranoside, isolated from the aerial parts of the fern Ophioglossum vulgatum L., exhibits wound healing activity [1].

3-Oxo-7-hydroxychol-4-enoic acid, an endogenous metabolite, is potentially a significant prognostic marker for adverse outcomes in hepatobiliary disease [1].

6-(3-Methyl-2-oxobutyroyl)-7-methoxycoumarin is a natural product for research related to life sciences. The catalog number is TN5877 and the CAS number is 2188162-96-9.

1-(3,4-Dihydroxyphenyl)-7-(4-hydroxyphenyl)hept-6-en-3-ol is a natural product for research related to life sciences. The catalog number is TN2471 and the CAS number is 1206788-61-5.

7-Hydroxy-3-(4-hydroxybenzyl)chroman shows moderate inhibitory activity against a chymotrypsin-like activity of the proteasome.

RXFP1 receptor agonist-7 (Example 2) serves as an RXFP1 receptor agonist, effectively inhibiting cAMP production in HEK293 cells that stably express the human RXFP1, achieving an EC50 of 4.2 nM [1].