tripterygium

Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.

Wilforol A is a natural product from Tripterygium wilfordii Hook. f.

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.

Triptotriterpenic acid C, an ursolic-type compound, can be isolated from the total glycosides extracted from the root of Tripterygium wilfordii Hook.f [1].

Dulcioic acid shows a significant inhibitory effect on cytokine production.

Wilforlide A (T1) serves as a quality control standard of Tripterygium Glycosides that be listed in Drug Standard of Ministry of Public Health of the People's Republic of China. T1 has anti-inflammatory effects.

Wilfortrine can induce liver cancer cell HepG2 apoptosis, but with no effect on the cell cycle, mainly by promoting Bax expression and inhibiting anti-apoptotic protein Bcl-2 expression.

Regelin is an antitumor ursene-type triterpenoid isolated from Tripterygium regelii.

Wilfornine A is a natural product from Schisandra sphenanthera.

3,22-Dihydroxyolean-12-en-29-oic acid is a natural product for research related to life sciences. The catalog number is TN2860 and the CAS number is 808769-54-2.

Triptonoterpene Me ether (compound 5), a rosinane-type diterpenoid, is derived from the traditional Chinese medicinal plant, Tripterygium wilfordii Hook. f [1].

Triptonodiol is a natural product from Tripterygium wilfordii Hook.f.

Epikatonic acid shows less active against T. (S.) cruzi trypanosome.

3-Hydroxy-12-oleanene-23,28-dioic acid is a natural product for research related to life sciences. The catalog number is TN2937 and the CAS number is 226562-47-6.

Tripdiolide has cytotoxic, and anti-rheumatic activities, it suppresses pro-inflammatory gene expression, may be effective therapy for lupus nephritis.

Triptonoditerpenic acid is an aromatic pimarane diterpenoid that can be isolated from Tripterygium wilfordii. It exhibits cytotoxicity against HepG2, Hep3B, and Bcap37 cell lines, with IC50 values of 42.53 μM, 29.74 μM, and 37.63 μM, respectively.

Triptobenzene H shows the significant immunosuppressive activity.

2-Picenecarboxylic acid is a natural product for research related to life sciences. The catalog number is TN2793 and the CAS number is 118172-80-8.

Triptonoterpenol (Compound 6) is a secondary metabolite derived from Tripterygium wilfordii [1].

Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells, it shows the significant immunosuppressive activity.

Neotripterifordin shows potent anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 25 nM and TI of 125.

Neotriptophenolide is a natural product

Triptinin A and triptinin B are leukotriene D4 antagonist constituents.

Triptoquinone H, a natural product derived from the traditional Chinese medicinal plant Tripterygium hypoglaucu, exhibits potent cytotoxic, immunomodulatory, and anti-inflammatory properties. It is utilized in research concerning cancer or inflammatory diseases [1].

1b-Benzoyl-8a-cinnamoyl-4a,5a-dihydroxydihydroagarofuran is a sesquiterpenoid isolated from the root bark of Tripterygium hypoglaucum, characterized by the presence of both a benzoyl and a cinnamoyl group [1].

Triptonine B demonstrates potent anti-HIV activity with an EC(50) value of <0.10 microg/mL and an in vitro therapeutic index value of >1000.

Triptohypol F is a natural product for research related to life sciences. The catalog number is TN5184 and the CAS number is 268541-26-0.

Zeorin shows strong inhibition activity against bacteria and fungi. It markedly exhibits inhibitory activity on histamine release from mast cell induced by DNP24-BSA, it shows potent inhibitory effect by 40% decrease of histamine release.

Wilforlide A (3-Epiabruslactone A) is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, but has no significant immune suppressive activity.

Wilfordine is an insecticidally active alkaloid, Na+-K+-ATPase may be an acting target of wilfordine against some larvae of insect.

Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.

1. Triptonide (PG 492) is effective in the treatment of autoimmune diseases and has potent antileukemic and antitumor activities. 2. Triptonide possesses anti-inflammatory activity, upregulate the expression of IL-37, and this expression was suppressed by ERK1/2 and p38 MAPK inhibitors.

Triptotriterpenic acid A (Abrusgenic acid) is isolated from Tripterygium wilfordii and has potential hepatotoxicity for the study of rheumatoid arthritis.

Tripterifordin shows anti-HIV replication activity in H9 lymphocyte cells with an EC50 of 1 microgram/ml.

Epicatechin pentaacetate is a phenolic compound from the V. mullaha fruit extracts, the utilization of V. mullaha fruit as functional food with prospective pharmaceutical, nutraceuticals and cosmeceutical properties.

Triptonoterpene is a natural product found in Tripterygium wilfordii and Tripterygium doianum. Triptonoterpene is an abietane diterpenoid.

Triptoquinonide is a natural product from Tripterygium wilfordii.

1. Wilforgine exhibits insecticidal activity of some degree.

Triptocallic acid D is a natural product for research related to life sciences. The catalog number is TN5182 and the CAS number is 201534-09-0.

Wilforol C is a natural product for research related to life sciences. The catalog number is TN5256 and the CAS number is 168254-95-3.

Triptocalline A, a compound from Salacia chinensis, inhibits rat lens aldose reductase.

Triptophenolide (Hypolide) is a compound isolated from Tripterygium wilfordii Hook with anti-inflammatory activity.

Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE co

Triptocallic acid A is a natural product for research related to life sciences. The catalog number is TN5181 and the CAS number is 190906-61-7.

Regelidine is a natural product from Tripterygium regelii.

Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be mediated by down-regulation of the expr

1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells. 2. Pristimerin down-regulates the expression of pro-inflammatory mediators through blocking of NF-κB activation by inhibiting interconnected ROS/IKK/NF-κB signaling pathways, can effectively inhibit both arthritic inflammation and cartilage and bone damage in the joints.

Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synth

Euojaponine D is a natural product