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trpv-3 antagonist 74a

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    50
    TargetMol | Activity
  • Peptide Products
    1
    TargetMol | inventory
  • Recombinant Protein
    11
    TargetMol | natural
TRPV3 antagonist 74a
T374291432051-63-2
TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
  • $499
In Stock
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QTY
TRPM8 antagonist WS-3
T596239711-79-0
TRPM8 antagonist WS-3 (Cyclohexanecarboxamide) is an agonist of TRPM8( EC50 : 3.7 μM).
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
5-HT3 antagonist 3
T10162120635-47-4In house
5-HT3 antagonist 3 (Compound 15b) is a high-affinity 5-HT3 receptor antagonist that binds to 5-HT3 receptors in rat brain cortical membranes (Ki: 0.25 nM).
  • $117
In Stock
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QTY
TargetMol | Inhibitor Sale
AMPA receptor antagonist-3
T61813923272-18-8
AMPA receptor antagonist-3 is an AMPA receptor antagonist.
  • $195
In Stock
Size
QTY
Sigma-1 receptor antagonist 3
T129121639220-17-9In house
Sigma-1 receptor antagonist 3 is a potent and selective antagonist of Sigma-1 (σ1) receptor(Ki : 1.14 nM), has the potential for the neuropathic pain.
  • $81
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TRPM8 antagonist 3
T97092102179-29-1
TRPM8 antagonist 3 is a blocker of TRPM8 (IC50 = 11 nM).
  • $56
In Stock
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QTY
TargetMol | Inhibitor Sale
CCR2 antagonist 3
T107121380100-86-6
CCR2 antagonist 3 (AZD-2927) is an antagonist of CCR2.
  • $107
In Stock
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QTY
TargetMol | Inhibitor Sale
LPA5 antagonist 3
T868191664336-44-0
LPA5 antagonist 3 (Example 74), a lysophosphatidic acid receptor 5 (LPA5) antagonist, exhibits potent activity with an IC50 value of 170 nM. It is primarily utilized in the research of pain disorders and atherosclerosis [1].
  • Inquiry Price
10-14 weeks
Size
QTY
LTB4 antagonist 3
T786782929239-87-0
Compound 24e, a leukotriene B4 (LTB4) antagonist, exhibits an inhibitory concentration 50 (IC50) of 477 nM and demonstrates anti-inflammatory activity [1].
  • $1,970
8-10 weeks
Size
QTY
Calcium Channel antagonist 3
T77712687573-14-4
Calcium Channel antagonist 3 is a voltage-gated calcium channel inhibitor (IC50 : 5-20 μM).
  • $39
In Stock
Size
QTY
IL-17A antagonist 3
T116362230780-65-9
IL-17A antagonist 3 is an inhibitor of IL-17A.
  • $1,970
8-10 weeks
Size
QTY
EP3 antagonist 3
T613571227827-88-4
EP3 antagonist 3 (compound 2) is a potent and specific EP3 receptor antagonist with a significant pKi value of 8.3, high oral bioavailability, and excellent pharmacokinetic properties, making it ideal for experimental overactive bladder (OAB) research [1].
  • $954
6-8 weeks
Size
QTY
TRPV4 antagonist 3
T403062681273-35-6
TRPV4 antagonist 3 is a TRPV4 antagonist (pIC50 = 8.4).
  • $970
Backorder
Size
QTY
Adenosine receptor antagonist 3
T608722400864-80-2
Adenosine receptor antagonist 3 has the potential for cancer disease research which is a potent adenosine receptor antagonist [1].
  • $954
6-8 weeks
Size
QTY
Mu opioid receptor antagonist 3
T62767
Mu opioid receptor antagonist 3 (compound 26) is a potent and selective MOR antagonist with the ability to penetrate the blood-brain barrier (Ki: 0.24 nM, EC50: 0.54 nM). This compound can be used to study opioid use disorder (OUD).
  • $1,520
10-14 weeks
Size
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A1AR antagonist 3
T623482413257-73-3
A1AR antagonist 3 (compound 13) is a selective adenylate 1 (A1) receptor antagonist with an affinity for human A1 (Ki: 9.69 nM) and rat A1 (Ki: 0.529 nM). It is suitable for research on neurological diseases.
  • $1,520
6-8 weeks
Size
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Androgen receptor antagonist 3
T60987353484-46-5
Androgen receptor antagonist 3 (Compound C18) exhibits anticancer activity as an antagonist of the androgen receptor (AR) with an IC50 value of 2.4 μM [1].
  • $2,140
6-8 weeks
Size
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GPR84 antagonist 3
T629182815263-05-7
GPR84 Antagonist 3 (compound 42), a potent inhibitor of the G-protein-coupled receptor 84 (GPR84), exhibits a pIC50 value of 8.28, indicating strong antagonistic activity by inhibiting GTPγS. Additionally, it possesses a favorable pharmacokinetic profile, suitable for further research and development [1].
  • $1,520
10-14 weeks
Size
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GPVI antagonist 3
T61811901654-94-2
GPVI antagonist 3 (Compound 2) is a promising antiplatelet agent that selectively inhibits the interaction between the Glycoprotein VI (GPVI) receptor and its ligands. It demonstrates potent inhibitory effects with IC50 values of 1.01 μM for collagen, 1.92 μM for CRP, 7.24 μM for convulxin, and 51.74 μM for thrombin, positioning it as a potential novel antithrombotic treatment [1].
  • $1,520
6-8 weeks
Size
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Estrogen receptor antagonist 3
T639142730011-50-2
Estrogen receptor antagonist 3 is a potent degradation agent of the estrogen receptor (ER). Estrogen signaling systems regulate cell growth, differentiation, and apoptosis, and estrogen receptor antagonist 4 has shown potential for cancer research.
  • $2,140
8-10 weeks
Size
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GPR34 receptor antagonist 3
T82264
Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1 2 phosphorylation in a dose-dependent manner, demonstrating an IC50 value of 0.680 μM without significant cytotoxicity. Additionally, it displays antisensory activity in a mouse neuropathic pain model [1].
  • $129
7-10 days
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CCR8 antagonist 3
T86022912463-57-1
CCR8 antagonist 3 (compound 2), a potent inhibitor of CCR8, exhibits an IC 50 value of 0.062 µM and demonstrates stability in human microsomes [1].
  • Inquiry Price
10-14 weeks
Size
QTY
A1/A3 AR antagonist 3
T790272665804-57-7
A1/A3 AR Antagonist 3 is a dual A1R/A3R antagonist that demonstrates high affinity within the low-micromolar to nanomolar range, and is potentially useful in the research of chronic heart diseases [1].
  • $1,820
8-10 weeks
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Orexin receptor antagonist 3
T624531293282-55-9
Orexin receptor antagonist 3 (example 216) functions as an orexin receptor antagonist.
  • $1,620
6-8 weeks
Size
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A2A receptor antagonist 3
T627972738606-83-0
A2A receptor antagonist 3 (Example 92) is an adenosine A2A receptor antagonist (Ki: 0.4 nM) and a receptor (Ki: 1467 nM).
  • $2,140
6-8 weeks
Size
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Protease-Activated Receptor-1 antagonist 3
T63382
Protease-Activated Receptor-1 antagonist 3 is a potent antagonist of Protease-Activated Receptor-1 (IC50: 7 nM) and exhibits binding affinity to hERG K+ channels (IC50: 9 μM).
  • $1,520
10-14 weeks
Size
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MCHR1 antagonist 3
T119651069622-60-1
MCHR1 antagonist 3, a potent antagonist of the melanin-concentrating hormone receptor-1 (MCHR1), is employed for the regulation of energy metabolism.
  • $1,820
8-10 weeks
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Galectin-3 antagonist 2
T745382921603-02-1
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and demonstrates resistance to pharmaceutical interventions.
  • $1,520
8-10 weeks
Size
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hGPR91 antagonist 3
T628581314796-31-0
hGPR91 antagonist 3 is an orally active, potent, and selective hGPR91 antagonist. hGPR91 antagonist 3 is used to study hypertension, autoimmune diseases, and retinal angiogenesis. hGPR91 antagonist 3 has been shown to be effective in the treatment of hypertension, autoimmune disease, and retinal angiogenesis.
  • $149
In Stock
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AR antagonist 3
T60719349573-58-6
When administered intratumorally, AR antagonist 3 shows effective inhibition on the growth of tumor. AR antagonist 3 is a potent and selective antagonist of androgen receptor (AR) with an IC 50 of 0.47 μM. AR antagonist 3 dose-dependently decrease the FRET signal with an IC50 of 18.05 μM [1].
    7-10 days
    Inquiry
    NMDA receptor antagonist-3
    T60792
    NMDA receptor antagonist-3 is a NMDA receptor antagonist with a significan recovery rate (40.0%, at 100 μM) and safe toxicological characteristics in SH-SY5Y and human adipose mesenchymal stem cells.
    • $1,520
    10-14 weeks
    Size
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    CRTh2 antagonist 3
    T10890312928-72-6
    CRTh2 antagonist 3 is a powerful chemokine receptor homologous molecule expressed on Th2 cell (CRTh2) antagonists. CRTh2 antagonist 3 enhanced the activity of PDK1 on short peptide substrates with EC50 of 2 μM and Kd of 8.4 μM. CRTh2 antagonist 3 has the
      Inquiry
      SSTR5 antagonist 3
      T874412851454-42-5
      SSTR5 antagonist 3 (Compound 23) serves as a potent somatostatin receptor subtype 5 (SSTR5) antagonist, demonstrating oral activity and minimal hERG inhibition. It shows significant efficacy, with IC50 values of 2.8 nM in humans and 1.4 nM in mice. This compound is utilized in gallstone research [1].
      • Inquiry Price
      10-14 weeks
      Size
      QTY
      TRPV1 antagonist 3
      T61788
      TRPV1 antagonist 3 (Compound 7q) is a highly potent TRPV1 receptor antagonist with an IC50 of 2.66 nM against capsaicin. It exhibits selectivity in its mode of action, is orally bioavailable (60%), and can penetrate the central nervous system [1].
      • $987
      10-14 weeks
      Size
      QTY
      ET receptor antagonist 3
      T79575
      ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) research. This compound demonstrates efficacy in mitigating monocrotaline-induced PAH in a rat model [1].
      • Inquiry Price
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      CCR4 antagonist 3 hydrochloride
      T396622174938-71-5
      CCR4 antagonist 3 hydrochloride is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.
      • $955
      Backorder
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      P2X7 receptor antagonist-3
      T721981627900-92-8
      P2X7 receptor antagonist-3 is a potent inhibitor of the P2X7 receptor, with IC50 values of 4.2 nM in humans and 6.8 nM in rats, demonstrating its high efficacy across species.
      • $1,520
      6-8 weeks
      Size
      QTY
      CCR4 antagonist 3
      T396612174938-70-4
      CCR4 antagonist 3 is an orally active, potent and selective CCR4 antagonist. CCR4 antagonist 3, featuring a novel piperidinyl-azetidine motif, has IC 50 s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4 antagonist 3 has antitumor activity.
      • $970
      Backorder
      Size
      QTY
      MrgprX2 antagonist-3
      T402712642174-19-2
      MrgprX2 antagonist-3 is a potent inhibitor of MrgprX2. It holds promising potential for investigating skin inflammatory disorders.
      • $970
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      CXCR2 antagonist 3
      T613562647464-92-2
      CXCR2 antagonist 3 (compound 11h) is a highly effective inhibitor of CXC chemokine receptor 2 (CXCR2), displaying double-digit nanomolar potencies in inhibiting neutrophil infiltration into the air pouch. Additionally, it reduces neutrophil and MDSC infiltration while enhancing CD3+ T lymphocyte infiltration into Pan02 tumor tissues [1].
      • $2,140
      8-10 weeks
      Size
      QTY
      GABAB receptor antagonist 3
      T86484160415-40-7
      3 (example 3) acts as an antagonist to the GABAB receptor [1].
      • Inquiry Price
      10-14 weeks
      Size
      QTY
      H4R antagonist 3
      T777151003091-20-0
      H4R antagonist 3 is a novel histamine-4 receptor (H4R) antagonist with an EC50 <10 mM.H4R antagonist 3 has potential inflammatory activity for the study of autoimmune, allergic and ocular diseases.
      • $195
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      OT antagonist 3 analog
      T12335
      OT antagonist 3 analog is an analogue of OT antagonist 3.
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      CCR4 antagonist 3-1
      T603361957-01-3
      CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine ( MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.
      • $93
      In Stock
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      CXCR4 antagonist 3
      T61409
      CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. With its potential for research on the human immunodeficiency virus, CXCR4 antagonist 3 holds great promise [1].
      • $1,520
      10-14 weeks
      Size
      QTY
      EP4 receptor antagonist 3
      T385951207954-34-4
      EP4 receptor antagonist 3 is a highly potent and specific inhibitor of the EP4 receptor, intended for research purposes in studying EP4 receptor-mediated diseases, including acute and chronic pain, osteoarthritis, rheumatoid arthritis, and cancer.
      • $970
      Backorder
      Size
      QTY
      TRPA1 Antagonist 3
      T4082271291-80-0
      TRPA1 Antagonist 3 is a compound with photoswitchable properties that acts as an agonist on the TRPA1 channel, providing the ability for optical control.
      • $970
      Backorder
      Size
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      TRPV antagonist 1
      T101761192871-27-4
      TRPV antagonist 1 is an antagonist of transient receptor potential vanilloid (TRPV; IC50 < 250 nM).
      • $1,520
      6-8 weeks
      Size
      QTY