venetoclax

Venetoclax (ABT-199) is a Bcl-2 inhibitor (Ki<0.01 nM) with potent, selective, and orally active properties. Venetoclax has a 3-order-of-magnitude lower affinity for Bcl-xL and Bcl-W (Kis=48/245 nM). Venetoclax induces autophagy and apoptosis.

Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199), a highly potent, selective, and orally bioavailable inhibitor of Bcl-2, demonstrates a Ki value of less than 0.01 nM [1].

Venetoclax-d8 is a deuterated compound of Venetoclax.

ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax.

Ara-SH, a derivative of Cytarabine with a mercaptopropionic acid substitution, serves as the initiator for the self-assembly of a smart, co-loaded Cytarabine and Venetoclax nanoparticle (AV-NP), demonstrating notable synergistic antileukemia effects both in vitro and in vivo [1].