Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family. Xenin 8 acetate augments Arginine-induced insulin release (by 40%) and potentiates the glucagon responses to both Arginine (by 60%), Carbachol (by 50%).

Xenin-8 TFA, a C-terminal octapeptide derived from the 25-amino acid peptide Xenin belonging to the neurotensin/xenopsin family, is biologically active. It enhances basal insulin secretion and amplifies glucose-stimulated insulin release in a dose-dependent manner (EC50=0.16 nM) [1].

neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effects